Detailed information of TA system TA098678

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 2525111..2525930
• Replicon: chromosome
• Accession: NZ_CP027426
• Organism: Klebsiella oxytoca strain FDAARGOS_335

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: CEQ13_RS13415
• Protein ID: WP_004110819.1
• Coordinates: 2525111..2525368 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: CEQ13_RS13420
• Protein ID: WP_105889756.1
• Coordinates: 2525379..2525930 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ13_RS13400	2520884..2521660	-	777	WP_004099223.1	Uxu operon transcriptional regulator	-
CEQ13_RS13405	2521795..2523270	-	1476	WP_105889754.1	fructuronate reductase	-
CEQ13_RS13410	2523345..2524529	-	1185	WP_105889755.1	mannonate dehydratase	-
CEQ13_RS13415	2525111..2525368	+	258	WP_004110819.1	YjhX family toxin	Toxin
CEQ13_RS13420	2525379..2525930	+	552	WP_105889756.1	N-acetyltransferase	Antitoxin
CEQ13_RS13425	2525948..2527576	+	1629	WP_105889757.1	SAM-dependent methyltransferase	-
CEQ13_RS29185	2527867..2528544	-	678	WP_004099230.1	hypothetical protein	-
CEQ13_RS13430	2529172..2529939	-	768	WP_004099232.1	winged helix-turn-helix domain-containing protein	-
CEQ13_RS13435	2530312..2530860	+	549	WP_004099233.1	type 1 fimbrial major subunit FimA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (17-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T98678 WP_004110819.1 NZ_CP027426:2525111-2525368 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T98678 NZ_CP027426:2525111-2525368 [Klebsiella oxytoca]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCATATTCGCGATGCATC
AGGCCGCGTAACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAACTCATTAAGTCCGTCAACGGGCAGCCCTACCGTATCAATACCACCGGGCTGAACAACGTTCGCGCT
CAGCTGGACAACCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20163.07 Da
• Isoelectric Point: 6.5667

>AT98678 WP_105889756.1 NZ_CP027426:2525379-2525930 [Klebsiella oxytoca]
MTNHNFTFHITSERDADDIREVETRAFGFSKEADLVADLLNDESAHPGLSLLAKHNGKSVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGMGVGGLLIQSGIEHLKAMGSLAVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQRLSS
RPLGITGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT98678 NZ_CP027426:2525379-2525930 [Klebsiella oxytoca]
ATGACAAACCATAACTTCACCTTTCACATCACCTCAGAGCGTGATGCTGATGATATTCGCGAAGTTGAAACCCGGGCCTT
CGGCTTTAGCAAAGAGGCCGACCTGGTTGCCGATTTGCTCAACGATGAAAGTGCTCACCCGGGATTATCTCTGCTGGCCA
AACATAATGGAAAATCCGTTGGGCATATTTTGTTCACCCTGGCGACGTTCAAAGGGGAGTCTGACTCTCCGATGATGCAT
ATCCTTGCCCCCCTGGCGGTGGTGCCGGAATACCAGGGCATGGGTGTTGGCGGATTACTTATCCAAAGCGGTATTGAGCA
TCTGAAGGCAATGGGGAGCCTGGCGGTATTCGTTCTGGGACATGCCACTTATTACCCGCGGCATGGCTTTGAACCCTGTG
CCGGAGATAAAGGCTATCCGGCGCCTTATCCCATTCCCGAGGAGCATAAAGCCTGCTGGATGCTGCAGCGGCTTTCGTCC
CGGCCGCTGGGGATAACCGGTCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2