98677

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1185404..1185951 Replicon chromosome
Accession NZ_CP027426
Organism Klebsiella oxytoca strain FDAARGOS_335

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag CEQ13_RS07035 Protein ID WP_105889384.1
Coordinates 1185643..1185951 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag CEQ13_RS07030 Protein ID WP_105889383.1
Coordinates 1185404..1185640 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ13_RS07015 1181610..1182776 + 1167 WP_105889380.1 multidrug effflux MFS transporter -
CEQ13_RS07020 1182938..1183840 + 903 WP_105889381.1 N-acetylmuramic acid 6-phosphate etherase -
CEQ13_RS07025 1183865..1185298 + 1434 WP_105889382.1 PTS N-acetylmuramic acid transporter subunit IIBC -
CEQ13_RS07030 1185404..1185640 + 237 WP_105889383.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
CEQ13_RS07035 1185643..1185951 + 309 WP_105889384.1 CcdB family protein Toxin
CEQ13_RS07040 1186101..1187003 + 903 WP_004107039.1 DMT family transporter -
CEQ13_RS07045 1187007..1187264 - 258 WP_105889385.1 hypothetical protein -
CEQ13_RS07050 1187264..1188238 - 975 WP_105890668.1 Rpn family recombination-promoting nuclease/putative transposase -
CEQ13_RS07055 1188452..1188745 + 294 WP_064344023.1 hypothetical protein -
CEQ13_RS07060 1188769..1189710 - 942 WP_004107045.1 LacI family transcriptional regulator -
CEQ13_RS07065 1190005..1190316 + 312 WP_004107048.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11665.47 Da        Isoelectric Point: 7.2729

>T98677 WP_105889384.1 NZ_CP027426:1185643-1185951 [Klebsiella oxytoca]
MQYYVYKNTGRIAAYPYLLDVQSDIIGKRNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLSDGI

Download         Length: 309 bp

>T98677 NZ_CP027426:1185643-1185951 [Klebsiella oxytoca]
ATGCAGTATTACGTTTATAAGAATACAGGTCGAATTGCTGCGTATCCTTACCTCCTTGATGTACAGAGTGACATTATCGG
CAAGCGCAATACTCGGGTCGTGATTCCACTGTTTCCACTGAAAAACTATAAAGGTCCACGCGCCGATCGTTTAACACCGC
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGCATCCCACATCGTGTTCTGGGTGAAGAG
GTTTGTAATCTGAATCACCAGCGCGAAGTCGTTAAAGCTTCAATGGATTTTCTTTCCGACGGGATCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8839.01 Da        Isoelectric Point: 6.4624

>AT98677 WP_105889383.1 NZ_CP027426:1185404-1185640 [Klebsiella oxytoca]
MPAAKRNKQNVSVTLDPGLVKQAREVGINMSLTLTNALKSEIHSLEIARWQKENAQAIDYLNNLTEEHGLLSEEYRTF

Download         Length: 237 bp

>AT98677 NZ_CP027426:1185404-1185640 [Klebsiella oxytoca]
ATGCCAGCCGCAAAACGCAATAAGCAGAACGTCAGCGTGACACTGGACCCTGGCCTGGTCAAACAGGCTCGTGAGGTCGG
CATCAATATGTCTCTAACGTTGACTAACGCTCTAAAAAGCGAAATCCACAGCCTCGAAATAGCCCGCTGGCAAAAAGAAA
ATGCCCAGGCAATCGACTACCTCAATAATTTAACTGAGGAACATGGACTTCTCTCTGAGGAATACAGGACGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References