98676

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 592467..593059 Replicon chromosome
Accession NZ_CP027426
Organism Klebsiella oxytoca strain FDAARGOS_335

Toxin (Protein)


Gene name doc Uniprot ID A0A7H4PHG5
Locus tag CEQ13_RS04060 Protein ID WP_004105955.1
Coordinates 592467..592841 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2J4YM08
Locus tag CEQ13_RS04065 Protein ID WP_004105957.1
Coordinates 592838..593059 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ13_RS04040 587816..589159 - 1344 WP_105889231.1 glycoside-pentoside-hexuronide (GPH):cation symporter -
CEQ13_RS04045 589267..590133 + 867 WP_004105950.1 AraC family transcriptional regulator -
CEQ13_RS04050 590262..591905 + 1644 WP_105889232.1 glycoside hydrolase family 43 protein -
CEQ13_RS04055 591984..592487 + 504 WP_004105953.1 M48 family metallopeptidase -
CEQ13_RS04060 592467..592841 - 375 WP_004105955.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
CEQ13_RS04065 592838..593059 - 222 WP_004105957.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CEQ13_RS04070 593219..594208 + 990 WP_105889233.1 Gfo/Idh/MocA family oxidoreductase -
CEQ13_RS04075 594459..595427 + 969 WP_105889234.1 TerC family protein -
CEQ13_RS04080 595682..596929 + 1248 WP_004105963.1 serine/threonine transporter SstT -
CEQ13_RS04085 596944..597498 - 555 WP_004105965.1 YgjV family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13895.93 Da        Isoelectric Point: 6.0769

>T98676 WP_004105955.1 NZ_CP027426:c592841-592467 [Klebsiella oxytoca]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHYEGVNDIFELAATYWVAIARGHIFNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Download         Length: 375 bp

>T98676 NZ_CP027426:c592841-592467 [Klebsiella oxytoca]
ATGAAATGGGTGAGCGCAAGCGAAGTCATTGCCTTTCATGATCGCATTTTACAACATCTCCCCGGCGTTAAAGGTATGTC
CGATCCTGGTCGGGCGGAAGCCATAATTTATCGTGTACAGAACCGCTTTCACTATGAAGGGGTGAACGACATTTTTGAAC
TGGCTGCAACCTATTGGGTCGCTATCGCGCGTGGGCACATTTTTAATGATGGTAATAAGAGGACTGCTTTTTTTATCACC
ATGACGTTCCTGGCCCGCAATGGGTATCTTATCGCTGATGAAGATACCCGGTTGGAAGAACTCACTGTGCTGGCTGCGAC
AGGCGAAGCTACGGTAGTAGTTCTTGCTGATGCGTTACGGCAATTGGCGCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8185.19 Da        Isoelectric Point: 5.7996

>AT98676 WP_004105957.1 NZ_CP027426:c593059-592838 [Klebsiella oxytoca]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALTDR

Download         Length: 222 bp

>AT98676 NZ_CP027426:c593059-592838 [Klebsiella oxytoca]
ATGCGCTCTTATAGTACATCTGAAGCCAGACAGAATATTGCGGCCGTCATGGACGCCGCTGCCAGCGGAGAACCGATTGA
AATTACGCGGCGTGATGGAACGTCTAATGTTTTGATCAGTAAGGCTGAATATGAAACGTTTATGAATGCCAAACTTGATG
CGGAGTTTGATTTTATTATGCAGCGACACGGCCGCACAGTTAAGGCGTTGACCGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4PHG5

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4YM08

References