Detailed information of TA system TA098673

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1611741..1612270
• Replicon: chromosome
• Accession: NZ_CP027422
• Organism: Staphylococcus cohnii strain FDAARGOS_334

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A6N7XWP7
• Locus tag: CEQ12_RS08350
• Protein ID: WP_019468010.1
• Coordinates: 1611908..1612270 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A921LYV8
• Locus tag: CEQ12_RS08345
• Protein ID: WP_046207786.1
• Coordinates: 1611741..1611911 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ12_RS08320	1607552..1608031	+	480	WP_073346060.1	PH domain-containing protein	-
CEQ12_RS08325	1608024..1609529	+	1506	WP_105874044.1	PH domain-containing protein	-
CEQ12_RS08330	1609522..1610013	+	492	WP_046207783.1	PH domain-containing protein	-
CEQ12_RS08335	1610048..1610398	+	351	WP_046207784.1	holo-ACP synthase	-
CEQ12_RS08340	1610505..1611653	+	1149	WP_073346054.1	alanine racemase	-
CEQ12_RS08345	1611741..1611911	+	171	WP_046207786.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
CEQ12_RS08350	1611908..1612270	+	363	WP_019468010.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CEQ12_RS08355	1612613..1613614	+	1002	WP_046207787.1	PP2C family protein-serine/threonine phosphatase	-
CEQ12_RS08360	1613683..1614009	+	327	WP_046207788.1	anti-sigma factor antagonist	-
CEQ12_RS08365	1614011..1614493	+	483	WP_064209857.1	anti-sigma B factor RsbW	-
CEQ12_RS08370	1614468..1615238	+	771	WP_073346051.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13595.69 Da
• Isoelectric Point: 9.9426

>T98673 WP_019468010.1 NZ_CP027422:1611908-1612270 [Staphylococcus cohnii]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSEEKMQEVNNAIDISLGLHNIRNHRT

Nucleotide

• Length: 363 bp

>T98673 NZ_CP027422:1611908-1612270 [Staphylococcus cohnii]
ATGATGAGAAGAGGAGACGTTTATTTAGCTGATTTGTCACCAGTACAGGGTTCTGAACAAGGGGGAATAAGGCCCGTAGT
CATTATACAAAATGATACTGGTAACAAGTATAGTCCTACCGTAATTGTAGCTGCAATTACAGGTAGGATTAATAAAGCTA
AAATACCTACACATGTAGAAATAGAAAAAAGCAAGTATAAACTCGACAAAGATTCTGTTATATTATTAGAGCAAATACGG
ACGTTAGACAAGAACAGATTAAAAGAAAAGCTGACATATCTATCTGAAGAAAAAATGCAAGAAGTTAATAATGCTATAGA
TATTAGCCTAGGTTTACATAATATTAGAAATCATAGAACATAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6332.00 Da
• Isoelectric Point: 4.0121

>AT98673 WP_046207786.1 NZ_CP027422:1611741-1611911 [Staphylococcus cohnii]
MASFNQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYIISKNNNE

Nucleotide

• Length: 171 bp

>AT98673 NZ_CP027422:1611741-1611911 [Staphylococcus cohnii]
ATGGCAAGTTTTAATCAAAGCAGAAATCATAGTATTGAACAACTATTAAAAGAAGGCTATTCACAAATGGCTGACTTGAA
TCTCTCCCTTGCGGCGGAAGCATTTCCATTTGAATGTGAAGCTTGCGATTGCAATGAAGTCTACATTATATCTAAGAATA
ACAATGAATGA

Structures

Toxin

• AlphaFold DB: A0A6N7XWP7