Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1600362..1600876 Replicon chromosome
Accession NZ_CP027422
Organism Staphylococcus cohnii strain FDAARGOS_334

Toxin (Protein)


Gene name TsdT Uniprot ID A0A921J8Q4
Locus tag CEQ12_RS08290 Protein ID WP_046207776.1
Coordinates 1600670..1600876 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A921J6E7
Locus tag CEQ12_RS08285 Protein ID WP_046207775.1
Coordinates 1600362..1600655 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ12_RS08265 1596021..1596659 + 639 WP_073346072.1 thiamine phosphate synthase -
CEQ12_RS08270 1596746..1597615 + 870 WP_046207772.1 membrane protein insertase YidC -
CEQ12_RS08275 1597815..1598459 - 645 WP_073346069.1 HD domain-containing protein -
CEQ12_RS08280 1598737..1600221 - 1485 WP_046207774.1 cardiolipin synthase -
CEQ12_RS08285 1600362..1600655 + 294 WP_046207775.1 copper-sensing transcriptional repressor CsoR Antitoxin
CEQ12_RS08290 1600670..1600876 + 207 WP_046207776.1 heavy-metal-associated domain-containing protein Toxin
CEQ12_RS08295 1601134..1601274 + 141 WP_099091318.1 hypothetical protein -
CEQ12_RS08300 1601541..1602728 - 1188 WP_070657370.1 rod shape-determining protein RodA -
CEQ12_RS08305 1602988..1604058 + 1071 WP_046207778.1 D-alanine--D-alanine ligase -
CEQ12_RS08310 1604071..1605426 + 1356 WP_073346065.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(20-65)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7973.09 Da        Isoelectric Point: 4.3611

>T98672 WP_046207776.1 NZ_CP027422:1600670-1600876 [Staphylococcus cohnii]
MESQTIYLRKIDNKQDKLQIERTLSQIIGVNHVSVEIEKAQVFIEFETPASLNNLEKDLYDLGFEILY

Download         Length: 207 bp

>T98672 NZ_CP027422:1600670-1600876 [Staphylococcus cohnii]
ATGGAATCACAAACGATTTATTTACGTAAAATAGATAATAAACAAGATAAGCTTCAAATAGAAAGAACATTATCACAAAT
CATAGGTGTGAATCATGTTTCAGTTGAAATTGAAAAAGCACAAGTGTTTATAGAATTTGAAACACCAGCAAGTTTAAACA
ATTTAGAAAAAGACTTATATGATTTAGGATTTGAAATTTTGTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11214.89 Da        Isoelectric Point: 6.8617

>AT98672 WP_046207775.1 NZ_CP027422:1600362-1600655 [Staphylococcus cohnii]
MAEMQKAHHSEQIKSNLKSRLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNQGEQ
QEAMDELLVTFQKLMKD

Download         Length: 294 bp

>AT98672 NZ_CP027422:1600362-1600655 [Staphylococcus cohnii]
ATGGCAGAAATGCAAAAAGCGCATCATTCTGAACAAATTAAATCAAATTTAAAATCTCGTTTAAATCGCATTGAAGGACA
AGTAAGAGCGATCAATCGTATGATTGATGAAGATGTATATTGTGATGATGTGCTTACACAAATTAGAGCGACAAGATCAG
CACTTAATAGTGTTGCTACGAAATTATTAGATCACCATATGAAAAGTTGTATTATGGATAAAGTGAACCAAGGTGAGCAA
CAAGAAGCAATGGATGAGTTGTTGGTAACTTTCCAAAAGTTAATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References