Detailed information of TA system TA098672

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 1600362..1600876
• Replicon: chromosome
• Accession: NZ_CP027422
• Organism: Staphylococcus cohnii strain FDAARGOS_334

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: A0A921J8Q4
• Locus tag: CEQ12_RS08290
• Protein ID: WP_046207776.1
• Coordinates: 1600670..1600876 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A921J6E7
• Locus tag: CEQ12_RS08285
• Protein ID: WP_046207775.1
• Coordinates: 1600362..1600655 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ12_RS08265	1596021..1596659	+	639	WP_073346072.1	thiamine phosphate synthase	-
CEQ12_RS08270	1596746..1597615	+	870	WP_046207772.1	membrane protein insertase YidC	-
CEQ12_RS08275	1597815..1598459	-	645	WP_073346069.1	HD domain-containing protein	-
CEQ12_RS08280	1598737..1600221	-	1485	WP_046207774.1	cardiolipin synthase	-
CEQ12_RS08285	1600362..1600655	+	294	WP_046207775.1	copper-sensing transcriptional repressor CsoR	Antitoxin
CEQ12_RS08290	1600670..1600876	+	207	WP_046207776.1	heavy-metal-associated domain-containing protein	Toxin
CEQ12_RS08295	1601134..1601274	+	141	WP_099091318.1	hypothetical protein	-
CEQ12_RS08300	1601541..1602728	-	1188	WP_070657370.1	rod shape-determining protein RodA	-
CEQ12_RS08305	1602988..1604058	+	1071	WP_046207778.1	D-alanine--D-alanine ligase	-
CEQ12_RS08310	1604071..1605426	+	1356	WP_073346065.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (20-65)

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7973.09 Da
• Isoelectric Point: 4.3611

>T98672 WP_046207776.1 NZ_CP027422:1600670-1600876 [Staphylococcus cohnii]
MESQTIYLRKIDNKQDKLQIERTLSQIIGVNHVSVEIEKAQVFIEFETPASLNNLEKDLYDLGFEILY

Nucleotide

• Length: 207 bp

>T98672 NZ_CP027422:1600670-1600876 [Staphylococcus cohnii]
ATGGAATCACAAACGATTTATTTACGTAAAATAGATAATAAACAAGATAAGCTTCAAATAGAAAGAACATTATCACAAAT
CATAGGTGTGAATCATGTTTCAGTTGAAATTGAAAAAGCACAAGTGTTTATAGAATTTGAAACACCAGCAAGTTTAAACA
ATTTAGAAAAAGACTTATATGATTTAGGATTTGAAATTTTGTATTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11214.89 Da
• Isoelectric Point: 6.8617

>AT98672 WP_046207775.1 NZ_CP027422:1600362-1600655 [Staphylococcus cohnii]
MAEMQKAHHSEQIKSNLKSRLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNQGEQ
QEAMDELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT98672 NZ_CP027422:1600362-1600655 [Staphylococcus cohnii]
ATGGCAGAAATGCAAAAAGCGCATCATTCTGAACAAATTAAATCAAATTTAAAATCTCGTTTAAATCGCATTGAAGGACA
AGTAAGAGCGATCAATCGTATGATTGATGAAGATGTATATTGTGATGATGTGCTTACACAAATTAGAGCGACAAGATCAG
CACTTAATAGTGTTGCTACGAAATTATTAGATCACCATATGAAAAGTTGTATTATGGATAAAGTGAACCAAGGTGAGCAA
CAAGAAGCAATGGATGAGTTGTTGGTAACTTTCCAAAAGTTAATGAAAGATTAG