Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4509345..4510002 Replicon chromosome
Accession NZ_CP027418
Organism Providencia rettgeri strain FDAARGOS_330

Toxin (Protein)


Gene name cptA Uniprot ID A0A1J0E9L4
Locus tag CEQ08_RS21020 Protein ID WP_042845040.1
Coordinates 4509345..4509755 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1J0E9J6
Locus tag CEQ08_RS21025 Protein ID WP_042845042.1
Coordinates 4509736..4510002 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ08_RS21000 4505284..4507017 - 1734 WP_042845035.1 single-stranded-DNA-specific exonuclease RecJ -
CEQ08_RS21005 4507027..4507731 - 705 WP_071548860.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CEQ08_RS21010 4507753..4508655 - 903 WP_042845037.1 site-specific tyrosine recombinase XerD -
CEQ08_RS21015 4508773..4509291 + 519 WP_042845038.1 flavodoxin FldB -
CEQ08_RS21020 4509345..4509755 - 411 WP_042845040.1 protein YgfX Toxin
CEQ08_RS21025 4509736..4510002 - 267 WP_042845042.1 FAD assembly factor SdhE Antitoxin
CEQ08_RS21030 4510252..4511241 + 990 WP_071548273.1 tRNA-modifying protein YgfZ -
CEQ08_RS21035 4511253..4511873 + 621 WP_071548274.1 HD domain-containing protein -
CEQ08_RS21040 4512028..4512924 + 897 WP_048607912.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15461.25 Da        Isoelectric Point: 10.6538

>T98670 WP_042845040.1 NZ_CP027418:c4509755-4509345 [Providencia rettgeri]
VVLWKSNLSISWKTQFFSTCVHGAVGMFLLVAPWAPAHSMIWLPLLAVVVASWAKSQKNISKIKGVAVLVNGNKVQWKKN
EWNIVKAPWLSRYGILLSLEALQGKQQKIHLWVAKDSVSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

>T98670 NZ_CP027418:c4509755-4509345 [Providencia rettgeri]
GTGGTCCTGTGGAAATCTAATCTTTCCATTTCATGGAAAACACAGTTTTTTTCAACCTGTGTTCATGGGGCAGTAGGCAT
GTTTTTGCTTGTTGCACCATGGGCACCGGCTCATTCAATGATATGGTTGCCACTTCTTGCGGTTGTGGTGGCTAGTTGGG
CAAAAAGCCAAAAGAACATCAGCAAAATAAAAGGGGTTGCTGTGTTGGTTAATGGTAATAAAGTCCAATGGAAAAAGAAT
GAATGGAATATTGTGAAAGCACCTTGGTTGAGCCGCTATGGCATCTTATTGTCATTAGAAGCTTTACAAGGTAAGCAACA
AAAAATTCACCTATGGGTTGCTAAAGACTCTGTTTCTGAGGAAAGTTGGCGTAATTTGAACCAATTATTACTTCAATACC
CTGATATTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10619.16 Da        Isoelectric Point: 4.8780

>AT98670 WP_042845042.1 NZ_CP027418:c4510002-4509736 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDSLTTNDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMVKLIQEKN
KNRGPVEI

Download         Length: 267 bp

>AT98670 NZ_CP027418:c4510002-4509736 [Providencia rettgeri]
ATGGATATTGAGAACAAGGCGCGAATTCATTGGGCTTGTCGCCGCGGTATGCGTGAGCTAGATATTTCAATCATGCCATT
TTTTGAGTATGAATATGATAGTCTGACAACCAATGATAAACAGGTGTTTGTCCGTTTATTGGAGTGTGCGGACCCTGATT
TATTTAACTGGTTAATGAATCACGGTCGCCCAGATGACGACGAGCTATTTCGTATGGTAAAACTGATTCAGGAAAAAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E9L4

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E9J6

References