Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2307267..2307913 Replicon chromosome
Accession NZ_CP027418
Organism Providencia rettgeri strain FDAARGOS_330

Toxin (Protein)


Gene name Hha Uniprot ID A0A1J0E3F0
Locus tag CEQ08_RS10280 Protein ID WP_042846891.1
Coordinates 2307267..2307470 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1J0E3I4
Locus tag CEQ08_RS10285 Protein ID WP_042846890.1
Coordinates 2307545..2307913 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ08_RS10255 2303346..2303684 + 339 WP_042846895.1 P-II family nitrogen regulator -
CEQ08_RS10260 2303695..2304978 + 1284 WP_042846894.1 ammonium transporter AmtB -
CEQ08_RS10265 2305119..2305985 - 867 WP_042846893.1 acyl-CoA thioesterase II -
CEQ08_RS10270 2306225..2306683 + 459 WP_071547718.1 YbaY family lipoprotein -
CEQ08_RS10280 2307267..2307470 - 204 WP_042846891.1 hemolysin expression modulator Hha Toxin
CEQ08_RS10285 2307545..2307913 - 369 WP_042846890.1 Hha toxicity modulator TomB Antitoxin
CEQ08_RS10290 2308443..2309813 - 1371 WP_071547719.1 murein transglycosylase D -
CEQ08_RS10295 2309895..2310647 - 753 WP_042846888.1 hydroxyacylglutathione hydrolase -
CEQ08_RS10300 2310681..2311415 + 735 WP_042846887.1 methyltransferase domain-containing protein -
CEQ08_RS10305 2311412..2311882 - 471 WP_042846886.1 ribonuclease HI -
CEQ08_RS10310 2311937..2312698 + 762 WP_071547720.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8087.38 Da        Isoelectric Point: 6.9770

>T98668 WP_042846891.1 NZ_CP027418:c2307470-2307267 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 204 bp

>T98668 NZ_CP027418:c2307470-2307267 [Providencia rettgeri]
ATGACCAAATCTGATTATCTGATGCGTTTGAGAAAATGCACAACAATTGAAACACTTGAGCGTGTCATTGAAAAAAACAA
GTATGAACTATCTGATGATGAACTAGAGTTATTCTACTCAGCGGCAGATCATCGTCTTGCTGAACTCACTATGAATAAGC
TCTACGATAAAATTCCACCTTCTGTATGGAAGTTTGTTAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14123.05 Da        Isoelectric Point: 4.3849

>AT98668 WP_042846890.1 NZ_CP027418:c2307913-2307545 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSAQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWETMNQNLVSVLDDDLKCLTSKT

Download         Length: 369 bp

>AT98668 NZ_CP027418:c2307913-2307545 [Providencia rettgeri]
ATGGATGAATACTCACCCAAAAGACATGATATAGCAGAACTAAAATACTTATGTAACAGTCTCAATAGAGACGCTATCTT
AAGTTTGCAAAAAACCAACACACATTGGATTAACGATCTAAGCTCTGCACAAAGTGCAGCTCTAAATGAACTCATTGAAC
ATATCGCAGCTTTTGTCTGGCGATTTAAGATCAAATATCCAAAAGAAAATCTCGTTATATCATTAATTGAAGAGTACCTC
GATGAGACTTATGACTTATTTGGTAGCCCAGTCATCACATTAAGTGAAATTATAGATTGGGAAACTATGAATCAAAATCT
AGTTTCAGTGCTGGATGATGACCTAAAATGTCTGACCAGCAAAACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E3I4

References