Detailed information of TA system TA098667

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1909409..1909890
• Replicon: chromosome
• Accession: NZ_CP027417
• Organism: Oligella urethralis strain FDAARGOS_329

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CEQ07_RS09095
• Protein ID: WP_105885655.1
• Coordinates: 1909409..1909669 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A378XCL0
• Locus tag: CEQ07_RS09100
• Protein ID: WP_018574598.1
• Coordinates: 1909669..1909890 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ07_RS09070	1904945..1905949	+	1005	WP_036558932.1	aliphatic sulfonate ABC transporter substrate-binding protein	-
CEQ07_RS09075	1906037..1906801	+	765	WP_018026447.1	ABC transporter permease	-
CEQ07_RS09080	1906814..1907578	+	765	WP_018026448.1	ABC transporter ATP-binding protein	-
CEQ07_RS09085	1907614..1908921	+	1308	WP_105885654.1	FAD-binding oxidoreductase	-
CEQ07_RS09095	1909409..1909669	-	261	WP_105885655.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEQ07_RS09100	1909669..1909890	-	222	WP_018574598.1	hypothetical protein	Antitoxin
CEQ07_RS09105	1910268..1910498	+	231	WP_105885656.1	transposase	-
CEQ07_RS09110	1910468..1910755	+	288	WP_151457959.1	transposase	-
CEQ07_RS09115	1910990..1912000	-	1011	WP_105885018.1	IS5 family transposase	-
CEQ07_RS09120	1912371..1913009	-	639	Protein_1773	transposase	-
CEQ07_RS09125	1913048..1914103	-	1056	WP_105885658.1	IS3 family transposase	-
CEQ07_RS09130	1914100..1914441	-	342	WP_105885659.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-85)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10019.74 Da
• Isoelectric Point: 10.5129

>T98667 WP_105885655.1 NZ_CP027417:c1909669-1909409 [Oligella urethralis]
MFQVIYTAKALKSLSKLDKTQARLIVAWIEKNLVNSSNPRFTGKNIKGDLADWRYRVGNYRILCHIIDQTITIEVINIGH
RKDIYK

Nucleotide

• Length: 261 bp

>T98667 NZ_CP027417:c1909669-1909409 [Oligella urethralis]
ATGTTTCAAGTTATCTATACAGCAAAAGCATTAAAATCTTTATCAAAGCTAGATAAAACTCAAGCTCGTCTAATTGTCGC
TTGGATTGAAAAAAATTTAGTTAATAGCTCTAATCCTCGGTTTACAGGGAAAAATATTAAAGGGGATTTAGCTGATTGGA
GATATCGTGTTGGCAATTACCGCATCTTATGTCACATTATTGATCAAACTATAACCATTGAAGTTATTAATATTGGTCAT
CGTAAAGATATCTATAAATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8472.67 Da
• Isoelectric Point: 5.1710

>AT98667 WP_018574598.1 NZ_CP027417:c1909890-1909669 [Oligella urethralis]
MSIISVRLNATEERLFTEYAEFHGKSLSTLLKESLAEKMEEELDAKLLVEAKEYNKKNPETYTHQQVKEKLGL

Nucleotide

• Length: 222 bp

>AT98667 NZ_CP027417:c1909890-1909669 [Oligella urethralis]
ATGTCTATCATTAGTGTTCGCTTAAACGCCACCGAAGAGCGTCTTTTTACCGAATATGCAGAATTTCATGGTAAAAGCTT
ATCTACCTTACTCAAAGAAAGTTTGGCTGAAAAAATGGAAGAAGAATTAGACGCTAAGCTCCTTGTCGAAGCGAAAGAGT
ATAACAAAAAGAATCCTGAAACTTACACGCACCAACAAGTTAAAGAGAAGCTAGGGTTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A378XCL0