Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 991068..991656 Replicon chromosome
Accession NZ_CP027417
Organism Oligella urethralis strain FDAARGOS_329

Toxin (Protein)


Gene name hicA Uniprot ID A0A2N6Q9J5
Locus tag CEQ07_RS04660 Protein ID WP_026156779.1
Coordinates 991474..991656 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A095Z0F5
Locus tag CEQ07_RS04655 Protein ID WP_018025986.1
Coordinates 991068..991460 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ07_RS04635 987250..987735 - 486 WP_036560390.1 copper chaperone PCu(A)C -
CEQ07_RS04640 987746..988834 - 1089 WP_105885233.1 SCO family protein -
CEQ07_RS04645 988954..990129 - 1176 WP_048768124.1 nitrite reductase, copper-containing -
CEQ07_RS04650 990505..990936 - 432 Protein_900 transposase -
CEQ07_RS04655 991068..991460 - 393 WP_018025986.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CEQ07_RS04660 991474..991656 - 183 WP_026156779.1 type II toxin-antitoxin system HicA family toxin Toxin
CEQ07_RS04665 992072..993532 + 1461 WP_018025988.1 IMP dehydrogenase -
CEQ07_RS04670 993560..995152 + 1593 WP_026156780.1 glutamine-hydrolyzing GMP synthase -
CEQ07_RS04675 995313..996623 - 1311 WP_105885236.1 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 965440..1136332 170892


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6729.89 Da        Isoelectric Point: 11.5187

>T98665 WP_026156779.1 NZ_CP027417:c991656-991474 [Oligella urethralis]
INSKDLIKHLEANGWQLRNVRGSHHVFRHPTLPGHISVPHPKKDLGKGIVNKLLKQAGLK

Download         Length: 183 bp

>T98665 NZ_CP027417:c991656-991474 [Oligella urethralis]
ATAAATAGCAAAGACCTTATCAAACACCTTGAGGCAAATGGCTGGCAGCTTAGGAATGTACGGGGCTCGCATCATGTTTT
CCGTCACCCAACATTGCCTGGCCATATTAGCGTTCCGCACCCTAAAAAAGATTTGGGTAAAGGCATCGTTAATAAATTGC
TTAAACAGGCAGGTCTGAAATAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14475.32 Da        Isoelectric Point: 4.2198

>AT98665 WP_018025986.1 NZ_CP027417:c991460-991068 [Oligella urethralis]
MKYPIVIEPGDEHTAWGVVVPDLPGCFSAADEGVNEAIENAKEAIELWIEEALDNGEVVPKASSIDKYKDDPDYKDWIWA
IVEINPDLFDDHIERVNITLPKRILARIDAKAKEAGKSRSGYIAQLALTN

Download         Length: 393 bp

>AT98665 NZ_CP027417:c991460-991068 [Oligella urethralis]
ATGAAATATCCTATTGTTATTGAACCCGGTGATGAGCACACGGCTTGGGGCGTAGTGGTTCCTGATTTGCCAGGGTGTTT
TTCGGCCGCTGATGAAGGTGTGAATGAGGCAATTGAAAATGCCAAAGAGGCAATAGAGTTGTGGATTGAGGAAGCCTTGG
ATAATGGTGAAGTAGTTCCGAAAGCTAGTTCTATTGATAAATATAAGGATGATCCTGATTATAAAGACTGGATATGGGCT
ATCGTAGAGATTAATCCAGACTTATTTGATGATCATATCGAAAGAGTTAATATCACATTGCCTAAACGCATACTGGCTAG
GATTGATGCCAAAGCAAAAGAAGCTGGCAAAAGTCGTTCTGGTTATATCGCTCAATTGGCATTAACAAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N6Q9J5

Antitoxin

Source ID Structure
AlphaFold DB A0A095Z0F5

References