Detailed information of TA system TA098663

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 827298..827772
• Replicon: chromosome
• Accession: NZ_CP027417
• Organism: Oligella urethralis strain FDAARGOS_329

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: CEQ07_RS03875
• Protein ID: WP_105885175.1
• Coordinates: 827506..827772 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: CEQ07_RS03870
• Protein ID: WP_105885174.1
• Coordinates: 827298..827516 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ07_RS03850	822549..823559	+	1011	WP_105885170.1	relaxase/mobilization nuclease domain-containing protein	-
CEQ07_RS03855	823655..825679	+	2025	WP_192574358.1	topoisomerase C-terminal repeat-containing protein	-
CEQ07_RS03860	825690..825998	+	309	WP_105885172.1	hypothetical protein	-
CEQ07_RS03865	826571..827233	+	663	WP_105885173.1	hypothetical protein	-
CEQ07_RS03870	827298..827516	+	219	WP_105885174.1	TraY domain-containing protein	Antitoxin
CEQ07_RS03875	827506..827772	+	267	WP_105885175.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEQ07_RS03880	828395..829264	-	870	WP_105885176.1	protein kinase	-
CEQ07_RS03885	829242..829460	-	219	WP_105885177.1	hypothetical protein	-
CEQ07_RS03890	829575..829922	+	348	WP_105885178.1	helix-turn-helix domain-containing protein	-
CEQ07_RS12045	830675..830818	-	144	WP_192574359.1	hypothetical protein	-
CEQ07_RS03895	830840..831850	-	1011	WP_036561512.1	IS5 family transposase	-
CEQ07_RS11920	831924..832142	+	219	WP_151457944.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	800344..833271	32927

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-85)

Antitoxin

• Relaxosome protein TraY (4-47)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10487.29 Da
• Isoelectric Point: 10.2540

>T98663 WP_105885175.1 NZ_CP027417:827506-827772 [Oligella urethralis]
MAYKIFYSDKAKKELSKLDKPVAKRIHNFLIERVIQNPKQQGGFLKGTLAEFWRYRVGDYRIIAQIDEDILTVLVIRIAH
RKDVYDKY

Nucleotide

• Length: 267 bp

>T98663 NZ_CP027417:827506-827772 [Oligella urethralis]
TTGGCTTATAAGATTTTTTATTCAGATAAAGCAAAAAAAGAACTATCAAAACTTGATAAGCCCGTCGCTAAACGAATTCA
TAATTTTTTGATTGAAAGGGTAATCCAGAATCCAAAACAGCAAGGCGGTTTTTTAAAAGGGACATTAGCCGAGTTTTGGA
GGTATCGTGTTGGTGACTATCGAATCATTGCGCAAATCGATGAAGACATTTTAACCGTATTAGTGATTAGAATAGCGCAC
CGAAAAGATGTTTACGATAAATATTAG

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8260.37 Da
• Isoelectric Point: 5.1801

>AT98663 WP_105885174.1 NZ_CP027417:827298-827516 [Oligella urethralis]
MLAIRLPNEINERLSDLAKKTGRTKSFYAREAIEKHLEDLEDIYLAEHELEQVRSGKSKVYSAEEVGKELGL

Nucleotide

• Length: 219 bp

>AT98663 NZ_CP027417:827298-827516 [Oligella urethralis]
ATGTTAGCCATCAGATTACCGAACGAAATAAACGAACGATTAAGTGACTTAGCAAAAAAAACAGGGCGCACAAAATCTTT
CTATGCTCGAGAAGCGATCGAAAAACATTTAGAAGATTTAGAAGATATTTATTTAGCAGAACATGAATTAGAGCAGGTTC
GTTCTGGTAAGTCAAAAGTGTATTCAGCCGAAGAAGTGGGAAAAGAACTTGGCTTATAA