Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 827298..827772 Replicon chromosome
Accession NZ_CP027417
Organism Oligella urethralis strain FDAARGOS_329

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag CEQ07_RS03875 Protein ID WP_105885175.1
Coordinates 827506..827772 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag CEQ07_RS03870 Protein ID WP_105885174.1
Coordinates 827298..827516 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ07_RS03850 822549..823559 + 1011 WP_105885170.1 relaxase/mobilization nuclease domain-containing protein -
CEQ07_RS03855 823655..825679 + 2025 WP_192574358.1 topoisomerase C-terminal repeat-containing protein -
CEQ07_RS03860 825690..825998 + 309 WP_105885172.1 hypothetical protein -
CEQ07_RS03865 826571..827233 + 663 WP_105885173.1 hypothetical protein -
CEQ07_RS03870 827298..827516 + 219 WP_105885174.1 TraY domain-containing protein Antitoxin
CEQ07_RS03875 827506..827772 + 267 WP_105885175.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEQ07_RS03880 828395..829264 - 870 WP_105885176.1 protein kinase -
CEQ07_RS03885 829242..829460 - 219 WP_105885177.1 hypothetical protein -
CEQ07_RS03890 829575..829922 + 348 WP_105885178.1 helix-turn-helix domain-containing protein -
CEQ07_RS12045 830675..830818 - 144 WP_192574359.1 hypothetical protein -
CEQ07_RS03895 830840..831850 - 1011 WP_036561512.1 IS5 family transposase -
CEQ07_RS11920 831924..832142 + 219 WP_151457944.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 800344..833271 32927


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-85)

Antitoxin

Relaxosome protein TraY

(4-47)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10487.29 Da        Isoelectric Point: 10.2540

>T98663 WP_105885175.1 NZ_CP027417:827506-827772 [Oligella urethralis]
MAYKIFYSDKAKKELSKLDKPVAKRIHNFLIERVIQNPKQQGGFLKGTLAEFWRYRVGDYRIIAQIDEDILTVLVIRIAH
RKDVYDKY

Download         Length: 267 bp

>T98663 NZ_CP027417:827506-827772 [Oligella urethralis]
TTGGCTTATAAGATTTTTTATTCAGATAAAGCAAAAAAAGAACTATCAAAACTTGATAAGCCCGTCGCTAAACGAATTCA
TAATTTTTTGATTGAAAGGGTAATCCAGAATCCAAAACAGCAAGGCGGTTTTTTAAAAGGGACATTAGCCGAGTTTTGGA
GGTATCGTGTTGGTGACTATCGAATCATTGCGCAAATCGATGAAGACATTTTAACCGTATTAGTGATTAGAATAGCGCAC
CGAAAAGATGTTTACGATAAATATTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8260.37 Da        Isoelectric Point: 5.1801

>AT98663 WP_105885174.1 NZ_CP027417:827298-827516 [Oligella urethralis]
MLAIRLPNEINERLSDLAKKTGRTKSFYAREAIEKHLEDLEDIYLAEHELEQVRSGKSKVYSAEEVGKELGL

Download         Length: 219 bp

>AT98663 NZ_CP027417:827298-827516 [Oligella urethralis]
ATGTTAGCCATCAGATTACCGAACGAAATAAACGAACGATTAAGTGACTTAGCAAAAAAAACAGGGCGCACAAAATCTTT
CTATGCTCGAGAAGCGATCGAAAAACATTTAGAAGATTTAGAAGATATTTATTTAGCAGAACATGAATTAGAGCAGGTTC
GTTCTGGTAAGTCAAAAGTGTATTCAGCCGAAGAAGTGGGAAAAGAACTTGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References