Detailed information of TA system TA098661

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 513399..514047
• Replicon: chromosome
• Accession: NZ_CP027417
• Organism: Oligella urethralis strain FDAARGOS_329

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CEQ07_RS02385
• Protein ID: WP_048766957.1
• Coordinates: 513399..513569 (+)
• Length: 57 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A2X1WQN7
• Locus tag: CEQ07_RS02390
• Protein ID: WP_048766959.1
• Coordinates: 513634..514047 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ07_RS02365	509066..511303	+	2238	WP_105885053.1	glycoside hydrolase family 31 protein	-
CEQ07_RS02370	511316..512242	+	927	WP_036557375.1	DMT family transporter	-
CEQ07_RS02380	512525..513091	-	567	Protein_461	site-specific integrase	-
CEQ07_RS02385	513399..513569	+	171	WP_048766957.1	type II toxin-antitoxin system HicA family toxin	Toxin
CEQ07_RS02390	513634..514047	+	414	WP_048766959.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CEQ07_RS12010	514116..514289	-	174	WP_168160356.1	hypothetical protein	-
CEQ07_RS02395	514677..516650	+	1974	WP_105885054.1	cation:proton antiporter	-
CEQ07_RS02400	516852..517778	+	927	WP_018026857.1	DMT family transporter	-
CEQ07_RS02405	517791..518681	-	891	WP_018026856.1	NAD(P)H-hydrate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-56)

Antitoxin

• Cro/C1-type helix-turn-helix domain (87-133)

Sequences

Toxin

Protein

• Length: 57 a.a.
• Molecular weight: 6460.54 Da
• Isoelectric Point: 11.1497

>T98661 WP_048766957.1 NZ_CP027417:513399-513569 [Oligella urethralis]
VKTSEFRRWLKSQGVEFKEGSKHTKLTYKGKHSTLPRHAKELPEGTRKAILKQLGL

Nucleotide

• Length: 171 bp

>T98661 NZ_CP027417:513399-513569 [Oligella urethralis]
GTGAAAACCAGCGAATTTAGACGCTGGCTGAAATCGCAAGGTGTTGAATTTAAGGAAGGCTCAAAACACACGAAGCTAAC
CTACAAAGGCAAACACAGTACCTTACCAAGGCACGCTAAAGAGCTACCAGAAGGCACTAGAAAAGCGATTTTAAAGCAGC
TAGGTTTGTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15487.95 Da
• Isoelectric Point: 4.9561

>AT98661 WP_048766959.1 NZ_CP027417:513634-514047 [Oligella urethralis]
MKYPFVLTPDAPGFTVTFPDLPEAITYGETKEEAIDLAYDCLVTALDFYFDDMRAVPEPSKVKDEQYAVTLPASVTVKVK
LLNEMTKQRIKQADLARLMNLSPTQVNRMVNLHRATKVDTLDRAFKALGKTLEFEVI

Nucleotide

• Length: 414 bp

>AT98661 NZ_CP027417:513634-514047 [Oligella urethralis]
ATGAAATATCCATTTGTGCTAACGCCTGACGCTCCAGGCTTTACGGTGACGTTTCCTGACTTACCAGAGGCCATAACATA
CGGGGAAACCAAAGAAGAAGCTATTGACTTAGCTTACGATTGTCTAGTTACGGCGCTAGATTTTTATTTTGATGATATGC
GTGCCGTGCCGGAACCATCTAAAGTGAAGGATGAACAGTACGCTGTTACGCTTCCAGCAAGCGTGACAGTTAAAGTCAAG
CTATTAAACGAAATGACAAAGCAGCGCATCAAACAAGCAGACTTGGCACGATTAATGAATTTATCACCAACGCAAGTAAA
CCGTATGGTTAATTTACATCGGGCTACAAAAGTAGATACTCTGGATCGAGCTTTTAAAGCTTTAGGTAAGACCCTAGAAT
TTGAAGTAATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2X1WQN7