Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 32086..33709 Replicon plasmid unnamed
Accession NZ_CP027411
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain FDAARGOS_319

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag CEP97_RS00165 Protein ID WP_000088046.1
Coordinates 32086..33411 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag CEP97_RS00170 Protein ID WP_024136327.1
Coordinates 33416..33709 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP97_RS00140 28484..29188 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
CEP97_RS00145 29800..30225 - 426 WP_001043843.1 hypothetical protein -
CEP97_RS00150 30479..31294 - 816 WP_001572439.1 HNH endonuclease -
CEP97_RS00155 31307..31717 - 411 WP_000985911.1 hypothetical protein -
CEP97_RS00160 31819..32025 - 207 WP_000134171.1 hypothetical protein -
CEP97_RS00165 32086..33411 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
CEP97_RS00170 33416..33709 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
CEP97_RS00180 34313..34705 - 393 WP_000341066.1 hypothetical protein -
CEP97_RS00185 35078..35419 + 342 WP_001151575.1 hypothetical protein -
CEP97_RS00190 35511..35702 + 192 WP_000398480.1 hypothetical protein -
CEP97_RS00195 35752..36033 + 282 WP_000077926.1 hypothetical protein -
CEP97_RS00200 36596..37837 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..232341 232341


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 65070.07 Da        Isoelectric Point: 5.5500

>T98658 WP_000088046.1 NZ_CP027411:c33411-32086 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 1326 bp

>T98658 NZ_CP027411:c33411-32086 [Salmonella enterica subsp. enterica serovar Heidelberg]
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Antitoxin


Download         Length: 98 a.a.        Molecular weight: 14441.32 Da        Isoelectric Point: 5.5500

>AT98658 WP_024136327.1 NZ_CP027411:c33709-33416 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFF

Download         Length: 294 bp

>AT98658 NZ_CP027411:c33709-33416 [Salmonella enterica subsp. enterica serovar Heidelberg]
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Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References