Detailed information of TA system TA098656

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 84672..85197
• Replicon: plasmid unnamed
• Accession: NZ_CP027409
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain FDAARGOS_317

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: CEP95_RS00535
• Protein ID: WP_001159863.1
• Coordinates: 84672..84977 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: CEP95_RS00540
• Protein ID: WP_000813641.1
• Coordinates: 84979..85197 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEP95_RS00495	80051..80611	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
CEP95_RS27350	80767..81054	+	288	WP_071530243.1	hypothetical protein	-
CEP95_RS00500	81331..81816	-	486	WP_000905606.1	membrane protein	-
CEP95_RS00505	81810..82319	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
CEP95_RS00515	82323..83036	-	714	Protein_96	EAL domain-containing protein	-
CEP95_RS00520	83045..83827	-	783	WP_000082169.1	site-specific integrase	-
CEP95_RS00525	83862..84383	-	522	WP_000198608.1	hypothetical protein	-
CEP95_RS00530	84380..84670	-	291	WP_001266176.1	hypothetical protein	-
CEP95_RS00535	84672..84977	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
CEP95_RS00540	84979..85197	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
CEP95_RS00545	85873..86394	+	522	WP_010999942.1	hypothetical protein	-
CEP95_RS00555	86878..87174	+	297	WP_001687482.1	hypothetical protein	-
CEP95_RS00560	87668..88657	+	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
CEP95_RS00565	88916..89360	-	445	Protein_105	site-specific integrase	-
CEP95_RS00570	89529..89910	-	382	Protein_106	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..220137	220137

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (21-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-90)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T98656 WP_001159863.1 NZ_CP027409:c84977-84672 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
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Nucleotide

• Length: 306 bp

>T98656 NZ_CP027409:c84977-84672 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT98656 WP_000813641.1 NZ_CP027409:c85197-84979 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT98656 NZ_CP027409:c85197-84979 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6