Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1615659..1616230 Replicon chromosome
Accession NZ_CP027404
Organism Helicobacter pylori strain FDAARGOS_300

Toxin (Protein)


Gene name relE Uniprot ID Q9ZKV4
Locus tag CEP79_RS07875 Protein ID WP_001880357.1
Coordinates 1615958..1616230 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9ZKV5
Locus tag CEP79_RS07870 Protein ID WP_001134119.1
Coordinates 1615659..1615910 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP79_RS07835 1611156..1612013 - 858 WP_000538063.1 SDR family oxidoreductase -
CEP79_RS07840 1612153..1612677 + 525 WP_001135603.1 acyl-CoA thioesterase -
CEP79_RS07845 1612752..1613054 - 303 WP_000889627.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
CEP79_RS07850 1613203..1614531 - 1329 WP_000867414.1 transposase -
CEP79_RS07855 1614559..1614753 + 195 Protein_1481 IS200/IS605 family transposase -
CEP79_RS07860 1614875..1615081 - 207 WP_000917077.1 hypothetical protein -
CEP79_RS08110 1615149..1615295 - 147 WP_000820666.1 hypothetical protein -
CEP79_RS07870 1615659..1615910 - 252 WP_001134119.1 hypothetical protein Antitoxin
CEP79_RS07875 1615958..1616230 - 273 WP_001880357.1 type II toxin-antitoxin system mRNA interferase toxin, HP0892 family Toxin
CEP79_RS07880 1616244..1616531 - 288 WP_001134114.1 type II toxin-antitoxin system antitoxin -
CEP79_RS07885 1617027..1619261 - 2235 WP_000716315.1 Hop family adhesin BabA -
CEP79_RS07905 1620263..1620673 - 411 WP_010882572.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1613203..1614531 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-90)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 91 a.a.        Molecular weight: 10484.42 Da        Isoelectric Point: 9.7463

>T98652 WP_001880357.1 NZ_CP027404:c1616230-1615958 [Helicobacter pylori]
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVGNLATEQPLEPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Download         Length: 273 bp

>T98652 NZ_CP027404:c1616230-1615958 [Helicobacter pylori]
ATGCTGACGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAATGGGTTTGATTTAAAGCTTTT
GTATAAAGTGGTTGGAAATTTAGCCACAGAGCAACCCCTAGAACCCAAATACAAAGACCACCCACTCAAAGGCGCTTTAA
AAGACTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACTCTTTTTTTA
GTAAGGCTAGGCAGTCATAGCGAGCTGTTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9500.57 Da        Isoelectric Point: 4.5821

>AT98652 WP_001134119.1 NZ_CP027404:c1615910-1615659 [Helicobacter pylori]
MPNTTNKDYTKYSQKQLFNLINQLEQKISQAFDDKRGCCLGHEIPNLETQQAIRGALNGENLEVIEDFSAWANEIKKEVN
AEN

Download         Length: 252 bp

>AT98652 NZ_CP027404:c1615910-1615659 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGATTACACAAAATACAGCCAAAAACAGCTTTTTAATCTCATCAATCAATTAGAGCAAAA
AATCAGCCAAGCTTTTGATGATAAAAGAGGTTGTTGTTTGGGGCATGAGATCCCAAACCTTGAAACGCAACAAGCCATAA
GAGGTGCGTTAAATGGCGAAAATTTAGAGGTTATTGAAGATTTTTCTGCATGGGCCAATGAAATCAAAAAGGAAGTGAAT
GCTGAAAATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1W0VLH9


Antitoxin

Source ID Structure
AlphaFold DB A0A1W0VLP4

References