Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/YafQ(toxin) |
Location | 1615659..1616230 | Replicon | chromosome |
Accession | NZ_CP027404 | ||
Organism | Helicobacter pylori strain FDAARGOS_300 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q9ZKV4 |
Locus tag | CEP79_RS07875 | Protein ID | WP_001880357.1 |
Coordinates | 1615958..1616230 (-) | Length | 91 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q9ZKV5 |
Locus tag | CEP79_RS07870 | Protein ID | WP_001134119.1 |
Coordinates | 1615659..1615910 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CEP79_RS07835 | 1611156..1612013 | - | 858 | WP_000538063.1 | SDR family oxidoreductase | - |
CEP79_RS07840 | 1612153..1612677 | + | 525 | WP_001135603.1 | acyl-CoA thioesterase | - |
CEP79_RS07845 | 1612752..1613054 | - | 303 | WP_000889627.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
CEP79_RS07850 | 1613203..1614531 | - | 1329 | WP_000867414.1 | transposase | - |
CEP79_RS07855 | 1614559..1614753 | + | 195 | Protein_1481 | IS200/IS605 family transposase | - |
CEP79_RS07860 | 1614875..1615081 | - | 207 | WP_000917077.1 | hypothetical protein | - |
CEP79_RS08110 | 1615149..1615295 | - | 147 | WP_000820666.1 | hypothetical protein | - |
CEP79_RS07870 | 1615659..1615910 | - | 252 | WP_001134119.1 | hypothetical protein | Antitoxin |
CEP79_RS07875 | 1615958..1616230 | - | 273 | WP_001880357.1 | type II toxin-antitoxin system mRNA interferase toxin, HP0892 family | Toxin |
CEP79_RS07880 | 1616244..1616531 | - | 288 | WP_001134114.1 | type II toxin-antitoxin system antitoxin | - |
CEP79_RS07885 | 1617027..1619261 | - | 2235 | WP_000716315.1 | Hop family adhesin BabA | - |
CEP79_RS07905 | 1620263..1620673 | - | 411 | WP_010882572.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 1613203..1614531 | 1328 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10484.42 Da Isoelectric Point: 9.7463
>T98652 WP_001880357.1 NZ_CP027404:c1616230-1615958 [Helicobacter pylori]
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVGNLATEQPLEPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVGNLATEQPLEPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF
Download Length: 273 bp
>T98652 NZ_CP027404:c1616230-1615958 [Helicobacter pylori]
ATGCTGACGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAATGGGTTTGATTTAAAGCTTTT
GTATAAAGTGGTTGGAAATTTAGCCACAGAGCAACCCCTAGAACCCAAATACAAAGACCACCCACTCAAAGGCGCTTTAA
AAGACTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACTCTTTTTTTA
GTAAGGCTAGGCAGTCATAGCGAGCTGTTTTGA
ATGCTGACGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAATGGGTTTGATTTAAAGCTTTT
GTATAAAGTGGTTGGAAATTTAGCCACAGAGCAACCCCTAGAACCCAAATACAAAGACCACCCACTCAAAGGCGCTTTAA
AAGACTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACTCTTTTTTTA
GTAAGGCTAGGCAGTCATAGCGAGCTGTTTTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9500.57 Da Isoelectric Point: 4.5821
>AT98652 WP_001134119.1 NZ_CP027404:c1615910-1615659 [Helicobacter pylori]
MPNTTNKDYTKYSQKQLFNLINQLEQKISQAFDDKRGCCLGHEIPNLETQQAIRGALNGENLEVIEDFSAWANEIKKEVN
AEN
MPNTTNKDYTKYSQKQLFNLINQLEQKISQAFDDKRGCCLGHEIPNLETQQAIRGALNGENLEVIEDFSAWANEIKKEVN
AEN
Download Length: 252 bp
>AT98652 NZ_CP027404:c1615910-1615659 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGATTACACAAAATACAGCCAAAAACAGCTTTTTAATCTCATCAATCAATTAGAGCAAAA
AATCAGCCAAGCTTTTGATGATAAAAGAGGTTGTTGTTTGGGGCATGAGATCCCAAACCTTGAAACGCAACAAGCCATAA
GAGGTGCGTTAAATGGCGAAAATTTAGAGGTTATTGAAGATTTTTCTGCATGGGCCAATGAAATCAAAAAGGAAGTGAAT
GCTGAAAATTAA
ATGCCAAACACCACCAACAAAGATTACACAAAATACAGCCAAAAACAGCTTTTTAATCTCATCAATCAATTAGAGCAAAA
AATCAGCCAAGCTTTTGATGATAAAAGAGGTTGTTGTTTGGGGCATGAGATCCCAAACCTTGAAACGCAACAAGCCATAA
GAGGTGCGTTAAATGGCGAAAATTTAGAGGTTATTGAAGATTTTTCTGCATGGGCCAATGAAATCAAAAAGGAAGTGAAT
GCTGAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1W0VLH9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1W0VLP4 |