Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1335265..1335922 Replicon chromosome
Accession NZ_CP027398
Organism Providencia stuartii strain FDAARGOS_291

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T1H2A7
Locus tag CEP70_RS06115 Protein ID WP_036941148.1
Coordinates 1335512..1335922 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID B2Q1I8
Locus tag CEP70_RS06110 Protein ID WP_004921708.1
Coordinates 1335265..1335531 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEP70_RS06095 1330296..1333172 + 2877 WP_072502434.1 aminomethyl-transferring glycine dehydrogenase -
CEP70_RS06100 1333391..1334011 - 621 WP_004921714.1 HD domain-containing protein -
CEP70_RS06105 1334023..1335012 - 990 WP_004921711.1 tRNA-modifying protein YgfZ -
CEP70_RS06110 1335265..1335531 + 267 WP_004921708.1 FAD assembly factor SdhE Antitoxin
CEP70_RS06115 1335512..1335922 + 411 WP_036941148.1 membrane protein Toxin
CEP70_RS06120 1335968..1336486 - 519 WP_014656387.1 flavodoxin FldB -
CEP70_RS06125 1336649..1337572 + 924 WP_072502433.1 site-specific tyrosine recombinase XerD -
CEP70_RS06130 1337592..1338296 + 705 WP_004921696.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CEP70_RS06135 1338302..1340035 + 1734 WP_004921693.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15289.15 Da        Isoelectric Point: 10.8779

>T98648 WP_036941148.1 NZ_CP027398:1335512-1335922 [Providencia stuartii]
VVLWKSNLSISWKTQLFSTCAHGVVGFILLVAPWAPGNSMVWLPLLVIVIASWAKSQKSISKIKGTAVLVNGNKVQWKKN
EWSIVKQPWCSRVGVLLTLSALQGKPQKIRLWVAKDALSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

>T98648 NZ_CP027398:1335512-1335922 [Providencia stuartii]
GTGGTCCTGTGGAAATCTAATCTCTCCATTTCATGGAAAACTCAGCTTTTTTCAACCTGTGCTCATGGGGTAGTCGGCTT
TATTCTATTGGTCGCACCATGGGCGCCAGGGAATTCAATGGTGTGGTTGCCGCTGTTAGTGATTGTGATTGCTAGCTGGG
CAAAAAGCCAAAAAAGCATCAGTAAAATCAAAGGGACTGCGGTGCTGGTTAATGGCAATAAAGTCCAATGGAAAAAGAAT
GAGTGGAGTATCGTTAAGCAACCTTGGTGTAGCCGTGTGGGGGTATTATTGACACTCAGTGCCTTACAAGGTAAGCCACA
GAAGATCCGTTTATGGGTTGCAAAAGATGCCTTATCAGAAGAGAGCTGGCGTAATTTAAACCAACTATTACTGCAATATC
CTGATATTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10576.10 Da        Isoelectric Point: 4.9104

>AT98648 WP_004921708.1 NZ_CP027398:1335265-1335531 [Providencia stuartii]
MDIENKARIHWACRRGMRELDISIMPFFEYEYEGLSDKDKRTFVRLLECADPDLFNWLMNHGRPDDDELFGMVKLIQERN
KNRGPVEI

Download         Length: 267 bp

>AT98648 NZ_CP027398:1335265-1335531 [Providencia stuartii]
ATGGATATAGAGAATAAAGCAAGAATTCATTGGGCTTGCCGTCGTGGTATGCGTGAGTTGGATATTTCCATCATGCCATT
CTTTGAATATGAATATGAAGGACTCTCTGACAAGGACAAGCGTACTTTTGTTCGTTTACTTGAGTGTGCAGACCCTGATC
TGTTTAACTGGTTAATGAATCATGGGCGCCCAGACGACGATGAGTTGTTTGGTATGGTTAAATTGATTCAGGAAAGAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1H2A7

Antitoxin

Source ID Structure
AlphaFold DB A0A140NIX0

References