Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4796575..4797110 Replicon chromosome
Accession NZ_CP027397
Organism Yersinia intermedia strain FDAARGOS_358

Toxin (Protein)


Gene name relE Uniprot ID A0A0T9M850
Locus tag CEQ36_RS22395 Protein ID WP_042568392.1
Coordinates 4796823..4797110 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0T9M846
Locus tag CEQ36_RS22390 Protein ID WP_032905973.1
Coordinates 4796575..4796826 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ36_RS22365 4792002..4792505 + 504 WP_042568395.1 ferredoxin-type protein NapF -
CEQ36_RS22370 4792495..4792761 + 267 WP_032905977.1 chaperone NapD -
CEQ36_RS22375 4792758..4795253 + 2496 WP_032905975.1 nitrate reductase catalytic subunit NapA -
CEQ36_RS22380 4795349..4795816 + 468 WP_042568394.1 nitrate reductase cytochrome c-type subunit -
CEQ36_RS22385 4795845..4796444 + 600 WP_042568393.1 cytochrome c-type protein NapC -
CEQ36_RS22390 4796575..4796826 + 252 WP_032905973.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CEQ36_RS22395 4796823..4797110 + 288 WP_042568392.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEQ36_RS22400 4797140..4797715 + 576 WP_042570012.1 GDP-mannose pyrophosphatase NudK -
CEQ36_RS22405 4798051..4800330 + 2280 WP_005183822.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
CEQ36_RS22410 4800417..4800872 - 456 WP_032905970.1 YaiI/YqxD family protein -
CEQ36_RS22415 4800872..4801798 - 927 WP_005183819.1 oxygen-dependent coproporphyrinogen oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.03 Da        Isoelectric Point: 10.3510

>T98646 WP_042568392.1 NZ_CP027397:4796823-4797110 [Yersinia intermedia]
MTYAVKFREEALKEWHKLDKTIQQQFAKKLKKCSDNPHIESAKLRGMKNCYKIKLRSSGFRLVYEVIDDVLIVAVVAVGK
RDRSEVYNLASDRLR

Download         Length: 288 bp

>T98646 NZ_CP027397:4796823-4797110 [Yersinia intermedia]
ATGACCTATGCCGTTAAGTTCAGAGAAGAAGCGCTAAAGGAATGGCACAAACTGGATAAGACGATACAACAGCAATTTGC
CAAGAAATTAAAAAAGTGCAGCGATAATCCGCATATTGAAAGCGCTAAACTACGTGGTATGAAAAACTGCTACAAAATTA
AATTACGATCCTCTGGATTTCGATTAGTGTATGAAGTTATCGATGATGTGTTGATCGTTGCTGTGGTTGCAGTAGGAAAA
AGAGATCGTAGCGAGGTGTATAACCTTGCAAGTGACCGATTACGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9255.56 Da        Isoelectric Point: 4.3287

>AT98646 WP_032905973.1 NZ_CP027397:4796575-4796826 [Yersinia intermedia]
MPSIILTDTSASVSELKKNPMATVNAGAGFPVAILNRNQPAFYCVPAELYEQIMEALDDHELAELVNRRRHQPLLDIDLD
SYL

Download         Length: 252 bp

>AT98646 NZ_CP027397:4796575-4796826 [Yersinia intermedia]
ATGCCAAGTATAATTTTGACTGATACCAGTGCCAGCGTGAGCGAACTGAAAAAAAATCCAATGGCAACAGTGAACGCTGG
GGCCGGTTTCCCCGTAGCTATCCTGAACCGCAATCAACCCGCATTCTATTGTGTACCCGCAGAACTATATGAACAAATAA
TGGAAGCGCTTGATGATCACGAATTAGCTGAGTTGGTTAACAGGCGGCGCCATCAACCCTTGCTTGATATCGATTTGGAT
AGCTATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9M850

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9M846

References