Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2111951..2112570 Replicon chromosome
Accession NZ_CP027397
Organism Yersinia intermedia strain FDAARGOS_358

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag CEQ36_RS10120 Protein ID WP_002208622.1
Coordinates 2112367..2112570 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0T9M685
Locus tag CEQ36_RS10115 Protein ID WP_005182270.1
Coordinates 2111951..2112319 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ36_RS10085 2107580..2107852 + 273 WP_080608411.1 type B 50S ribosomal protein L31 -
CEQ36_RS10090 2107855..2107998 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
CEQ36_RS10095 2108165..2109043 - 879 WP_005182278.1 metal ABC transporter substrate-binding protein -
CEQ36_RS10100 2109072..2109929 - 858 WP_050073431.1 metal ABC transporter permease -
CEQ36_RS10105 2109926..2110663 - 738 WP_050073470.1 ABC transporter ATP-binding protein -
CEQ36_RS10110 2111439..2111792 + 354 WP_032905603.1 hypothetical protein -
CEQ36_RS10115 2111951..2112319 + 369 WP_005182270.1 Hha toxicity modulator TomB Antitoxin
CEQ36_RS10120 2112367..2112570 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
CEQ36_RS10130 2113499..2113804 + 306 WP_186004081.1 MGMT family protein -
CEQ36_RS10135 2113895..2114449 - 555 WP_005182263.1 YbaY family lipoprotein -
CEQ36_RS10140 2114708..2115568 + 861 WP_080608412.1 acyl-CoA thioesterase II -
CEQ36_RS10145 2115648..2116937 - 1290 WP_032905738.1 ammonium transporter AmtB -
CEQ36_RS10150 2116977..2117315 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T98640 WP_002208622.1 NZ_CP027397:2112367-2112570 [Yersinia intermedia]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T98640 NZ_CP027397:2112367-2112570 [Yersinia intermedia]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTAGAACGTGTAATTGAAAAGAATAA
GTACGAGCTTTCCGATGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCATCGCCTGGCTGAACTCACAATGAATAAGC
TTTACGATAAAATTCCTCCTACGGTTTGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14222.93 Da        Isoelectric Point: 4.4314

>AT98640 WP_005182270.1 NZ_CP027397:2111951-2112319 [Yersinia intermedia]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYTCTLMKT

Download         Length: 369 bp

>AT98640 NZ_CP027397:2111951-2112319 [Yersinia intermedia]
ATGGATGAGTACTCGCCTAAACGGCATGACATTGCCCAGTTGAAGTTTCTATGTGAGAGCCTGTATGATGAAGGCATTGC
TACCCTTGGTGACAGCCATCATGGCTGGGTAAATGACCCAACATCTGCCGTAAATCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGACGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGATACATATACTCTGTTTAGTAGTTACGGAATCAATGATCCTGAATTGAGGCGCTGGCAAAAAACCAAAGAGCGCTT
ATTCAGACTTTTCTCAGGGGAATACACCTGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9M685

References