Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1289359..1289951 Replicon chromosome
Accession NZ_CP027397
Organism Yersinia intermedia strain FDAARGOS_358

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CEQ36_RS06025 Protein ID WP_050162496.1
Coordinates 1289359..1289613 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CEQ36_RS06030 Protein ID WP_080608272.1
Coordinates 1289610..1289951 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ36_RS06000 1284667..1284912 + 246 WP_192945372.1 DUF2732 family protein -
CEQ36_RS06005 1284924..1285142 + 219 WP_080608268.1 TraR/DksA family transcriptional regulator -
CEQ36_RS06010 1285139..1287409 + 2271 WP_080608269.1 replication endonuclease -
CEQ36_RS06015 1287522..1287716 + 195 WP_080608270.1 hypothetical protein -
CEQ36_RS06020 1288172..1289041 + 870 WP_080608271.1 DUF559 domain-containing protein -
CEQ36_RS06025 1289359..1289613 + 255 WP_050162496.1 type II toxin-antitoxin system HicA family toxin Toxin
CEQ36_RS06030 1289610..1289951 + 342 WP_080608272.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CEQ36_RS06040 1290753..1293716 + 2964 WP_192945337.1 NACHT domain-containing protein -
CEQ36_RS06045 1293795..1294814 - 1020 WP_105165846.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1273148..1314105 40957


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(55-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9523.08 Da        Isoelectric Point: 10.9085

>T98638 WP_050162496.1 NZ_CP027397:1289359-1289613 [Yersinia intermedia]
MNKRHQKTLLDVYARPVSGSIKWSDIEALFIGLGAEIHEREGSRIAVLLKGEKRIFHRPHPRPTTDKGAVNSIRLWLDSL
GIKP

Download         Length: 255 bp

>T98638 NZ_CP027397:1289359-1289613 [Yersinia intermedia]
ATGAACAAACGACACCAAAAGACGTTATTAGATGTATATGCTCGACCAGTAAGTGGTTCAATAAAGTGGTCTGATATTGA
AGCGCTTTTTATTGGATTAGGGGCAGAGATACACGAACGGGAAGGCTCAAGGATTGCGGTGCTGTTAAAAGGTGAAAAGC
GTATTTTTCACCGCCCCCACCCCAGACCGACCACTGATAAGGGAGCGGTTAACTCCATCAGGTTATGGCTTGACAGTTTA
GGAATAAAACCATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12537.12 Da        Isoelectric Point: 4.6983

>AT98638 WP_080608272.1 NZ_CP027397:1289610-1289951 [Yersinia intermedia]
MNNTMKIDGHTAIINFDPEIEMFRGEFIGLNGGADFYAYSVEELKKEGSLSLSVFLDECKKDGIEPYKSYSGKVTARLTP
ERHQALTVTAQATGHSINDLLNEGADLVMQKYT

Download         Length: 342 bp

>AT98638 NZ_CP027397:1289610-1289951 [Yersinia intermedia]
ATGAACAACACAATGAAAATTGACGGCCACACTGCCATCATCAACTTTGATCCAGAAATTGAAATGTTTCGGGGTGAGTT
TATCGGCTTGAATGGTGGCGCTGATTTCTACGCTTATAGTGTGGAAGAACTGAAAAAAGAGGGTTCACTCTCCCTATCGG
TATTTTTAGATGAGTGCAAAAAAGACGGTATCGAGCCGTATAAATCTTATAGCGGTAAAGTCACTGCACGGCTAACACCT
GAGCGCCATCAGGCACTCACTGTTACCGCTCAAGCTACCGGTCATTCGATCAATGACCTACTGAATGAAGGTGCAGATCT
GGTTATGCAGAAATATACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References