Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1969450..1969928 Replicon chromosome
Accession NZ_CP027390
Organism Escherichia coli strain 2015C-4944

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag AX062_RS11520 Protein ID WP_001303876.1
Coordinates 1969641..1969928 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag AX062_RS11515 Protein ID WP_000536233.1
Coordinates 1969450..1969641 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AX062_RS11480 1964830..1965600 - 771 WP_000451007.1 DUF1627 domain-containing protein -
AX062_RS11485 1965622..1966368 - 747 WP_000788742.1 ATP-binding protein -
AX062_RS11490 1966375..1967490 - 1116 WP_001205821.1 hypothetical protein -
AX062_RS11495 1967569..1968024 + 456 WP_000273724.1 hypothetical protein -
AX062_RS11500 1968231..1968656 - 426 WP_000693855.1 Rha family transcriptional regulator -
AX062_RS11505 1968640..1968912 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
AX062_RS11510 1969021..1969422 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
AX062_RS11515 1969450..1969641 + 192 WP_000536233.1 hypothetical protein Antitoxin
AX062_RS11520 1969641..1969928 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AX062_RS11525 1970205..1970357 + 153 WP_000380316.1 DUF1391 family protein -
AX062_RS11530 1970369..1971007 + 639 WP_000394543.1 hypothetical protein -
AX062_RS11535 1971008..1971217 - 210 WP_001133037.1 hypothetical protein -
AX062_RS11545 1971785..1971973 + 189 WP_000413705.1 cell division inhibition protein DicB -
AX062_RS11550 1971970..1972161 + 192 WP_001098307.1 DUF1482 family protein -
AX062_RS11555 1972255..1974705 + 2451 WP_000048583.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T98584 WP_001303876.1 NZ_CP027390:1969641-1969928 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T98584 NZ_CP027390:1969641-1969928 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT98584 WP_000536233.1 NZ_CP027390:1969450-1969641 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT98584 NZ_CP027390:1969450-1969641 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References