Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 937852..938378 | Replicon | chromosome |
| Accession | NZ_CP027390 | ||
| Organism | Escherichia coli strain 2015C-4944 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | AX062_RS05155 | Protein ID | WP_000323025.1 |
| Coordinates | 938091..938378 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | AX062_RS05150 | Protein ID | WP_000534858.1 |
| Coordinates | 937852..938091 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AX062_RS05115 | 933038..933265 | + | 228 | WP_000476993.1 | transcriptional regulator | - |
| AX062_RS05120 | 933249..933770 | + | 522 | WP_000705349.1 | hypothetical protein | - |
| AX062_RS05125 | 933751..934716 | + | 966 | WP_000054507.1 | hypothetical protein | - |
| AX062_RS05130 | 934757..935176 | + | 420 | WP_001151195.1 | DUF977 family protein | - |
| AX062_RS05135 | 935210..936550 | + | 1341 | WP_000589012.1 | ISNCY family transposase | - |
| AX062_RS05140 | 936987..937319 | - | 333 | WP_001317460.1 | FlxA-like family protein | - |
| AX062_RS05145 | 937522..937827 | - | 306 | WP_001326990.1 | hypothetical protein | - |
| AX062_RS05150 | 937852..938091 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| AX062_RS05155 | 938091..938378 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| AX062_RS05160 | 938450..938605 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| AX062_RS05165 | 938822..939073 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| AX062_RS05170 | 939140..939418 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| AX062_RS05175 | 939420..940469 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| AX062_RS05180 | 940483..941235 | + | 753 | WP_001047133.1 | antitermination protein | - |
| AX062_RS32365 | 941513..941602 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| AX062_RS05185 | 941657..941869 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| AX062_RS05190 | 942170..942385 | + | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| AX062_RS33040 | 942749..942919 | - | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| AX062_RS05195 | 943139..943354 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | espFu/tccP | 912100..1073452 | 161352 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T98574 WP_000323025.1 NZ_CP027390:938091-938378 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T98574 NZ_CP027390:938091-938378 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT98574 WP_000534858.1 NZ_CP027390:937852-938091 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT98574 NZ_CP027390:937852-938091 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|