Detailed information of TA system TA098543

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1756528..1757006
• Replicon: chromosome
• Accession: NZ_CP027388
• Organism: Escherichia coli strain 2011C-4251

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: C6P70_RS09960
• Protein ID: WP_001303876.1
• Coordinates: 1756719..1757006 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: C6P70_RS09955
• Protein ID: WP_000536233.1
• Coordinates: 1756528..1756719 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6P70_RS09920	1751908..1752678	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
C6P70_RS09925	1752760..1753446	-	687	WP_000788749.1	ATP-binding protein	-
C6P70_RS09930	1753453..1754568	-	1116	WP_001205820.1	hypothetical protein	-
C6P70_RS09935	1754647..1755102	+	456	WP_000273724.1	hypothetical protein	-
C6P70_RS09940	1755309..1755734	-	426	WP_000693855.1	Rha family transcriptional regulator	-
C6P70_RS09945	1755718..1755990	-	273	WP_000887453.1	helix-turn-helix domain-containing protein	-
C6P70_RS09950	1756099..1756500	+	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
C6P70_RS09955	1756528..1756719	+	192	WP_000536233.1	hypothetical protein	Antitoxin
C6P70_RS09960	1756719..1757006	+	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C6P70_RS09965	1757283..1757438	+	156	WP_000379575.1	DUF1391 family protein	-
C6P70_RS09975	1757580..1757969	+	390	WP_000394511.1	hypothetical protein	-
C6P70_RS09980	1758156..1758341	-	186	WP_001133046.1	hypothetical protein	-
C6P70_RS09990	1758915..1759103	+	189	WP_000413705.1	cell division inhibition protein DicB	-
C6P70_RS09995	1759100..1759291	+	192	WP_001098307.1	DUF1482 family protein	-
C6P70_RS10000	1759385..1761856	+	2472	WP_000034468.1	exonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleF / nleH2 / nleC / nleB2	1709518..1761856	52338

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T98543 WP_001303876.1 NZ_CP027388:1756719-1757006 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T98543 NZ_CP027388:1756719-1757006 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT98543 WP_000536233.1 NZ_CP027388:1756528-1756719 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT98543 NZ_CP027388:1756528-1756719 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA