Detailed information of TA system TA098522

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 5639186..5639664
• Replicon: chromosome
• Accession: NZ_CP027387
• Organism: Escherichia coli strain 2014C-3057

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: C6P73_RS30915
• Protein ID: WP_001303876.1
• Coordinates: 5639377..5639664 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: C6P73_RS30910
• Protein ID: WP_000536233.1
• Coordinates: 5639186..5639377 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6P73_RS30875	5634566..5635336	-	771	WP_000451007.1	DUF1627 domain-containing protein	-
C6P73_RS30880	5635358..5636104	-	747	WP_000788742.1	ATP-binding protein	-
C6P73_RS30885	5636111..5637226	-	1116	WP_001205821.1	hypothetical protein	-
C6P73_RS30890	5637305..5637760	+	456	WP_000273724.1	hypothetical protein	-
C6P73_RS30895	5637967..5638392	-	426	WP_000693855.1	Rha family transcriptional regulator	-
C6P73_RS30900	5638376..5638648	-	273	WP_000887453.1	helix-turn-helix domain-containing protein	-
C6P73_RS30905	5638757..5639158	+	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
C6P73_RS30910	5639186..5639377	+	192	WP_000536233.1	hypothetical protein	Antitoxin
C6P73_RS30915	5639377..5639664	+	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C6P73_RS30920	5639941..5640093	+	153	WP_000380316.1	DUF1391 family protein	-
C6P73_RS30925	5640105..5640743	+	639	WP_000394543.1	hypothetical protein	-
C6P73_RS30930	5640744..5640953	-	210	WP_001133037.1	hypothetical protein	-
C6P73_RS30940	5641521..5641709	+	189	WP_000413705.1	cell division inhibition protein DicB	-
C6P73_RS30945	5641706..5641897	+	192	WP_001098307.1	DUF1482 family protein	-
C6P73_RS30950	5641991..5644441	+	2451	WP_000048583.1	exonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5628309..5645748	17439

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T98522 WP_001303876.1 NZ_CP027387:5639377-5639664 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T98522 NZ_CP027387:5639377-5639664 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT98522 WP_000536233.1 NZ_CP027387:5639186-5639377 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT98522 NZ_CP027387:5639186-5639377 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA