Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 4620051..4620577 | Replicon | chromosome |
| Accession | NZ_CP027387 | ||
| Organism | Escherichia coli strain 2014C-3057 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | C6P73_RS24655 | Protein ID | WP_000323025.1 |
| Coordinates | 4620290..4620577 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | C6P73_RS24650 | Protein ID | WP_000534858.1 |
| Coordinates | 4620051..4620290 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C6P73_RS24615 | 4615237..4615464 | + | 228 | WP_000476993.1 | transcriptional regulator | - |
| C6P73_RS24620 | 4615448..4615969 | + | 522 | WP_000705349.1 | hypothetical protein | - |
| C6P73_RS24625 | 4615950..4616915 | + | 966 | WP_000054507.1 | hypothetical protein | - |
| C6P73_RS24630 | 4616956..4617375 | + | 420 | WP_001151195.1 | DUF977 family protein | - |
| C6P73_RS24635 | 4617409..4618749 | + | 1341 | WP_000589012.1 | ISNCY family transposase | - |
| C6P73_RS24640 | 4619186..4619518 | - | 333 | WP_001317460.1 | FlxA-like family protein | - |
| C6P73_RS24645 | 4619721..4620026 | - | 306 | WP_001326990.1 | hypothetical protein | - |
| C6P73_RS24650 | 4620051..4620290 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| C6P73_RS24655 | 4620290..4620577 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| C6P73_RS24660 | 4620649..4620804 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| C6P73_RS24665 | 4621021..4621272 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| C6P73_RS24670 | 4621339..4621617 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| C6P73_RS24675 | 4621619..4622668 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| C6P73_RS24680 | 4622682..4623434 | + | 753 | WP_001047133.1 | antitermination protein | - |
| C6P73_RS31225 | 4623712..4623801 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| C6P73_RS24685 | 4623856..4624068 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| C6P73_RS24690 | 4624369..4624584 | + | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| C6P73_RS31785 | 4624948..4625118 | - | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| C6P73_RS24695 | 4625338..4625553 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleC | 4602017..4715156 | 113139 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T98518 WP_000323025.1 NZ_CP027387:4620290-4620577 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T98518 NZ_CP027387:4620290-4620577 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT98518 WP_000534858.1 NZ_CP027387:4620051-4620290 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT98518 NZ_CP027387:4620051-4620290 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|