Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4028887..4029722 Replicon chromosome
Accession NZ_CP027387
Organism Escherichia coli strain 2014C-3057

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag C6P73_RS21340 Protein ID WP_000854757.1
Coordinates 4028887..4029264 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag C6P73_RS21345 Protein ID WP_001295723.1
Coordinates 4029354..4029722 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6P73_RS21300 4024407..4024880 + 474 WP_001105384.1 DNA gyrase inhibitor SbmC -
C6P73_RS21305 4025078..4026136 + 1059 WP_001200887.1 FUSC family protein -
C6P73_RS21310 4026308..4026637 + 330 WP_000450409.1 DUF496 family protein -
C6P73_RS21315 4026738..4026920 - 183 WP_024167529.1 ethanolamine utilization protein -
C6P73_RS31570 4027374..4027745 - 372 WP_001295631.1 IS110 family transposase -
C6P73_RS31575 4028561..4028674 - 114 WP_001161660.1 DUF957 domain-containing protein -
C6P73_RS21335 4028687..4028890 - 204 WP_000761705.1 hypothetical protein -
C6P73_RS21340 4028887..4029264 - 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
C6P73_RS21345 4029354..4029722 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C6P73_RS21350 4029885..4030106 - 222 WP_000692345.1 DUF987 domain-containing protein -
C6P73_RS21355 4030175..4030651 - 477 WP_001186725.1 RadC family protein -
C6P73_RS21360 4030667..4031152 - 486 WP_000849582.1 antirestriction protein -
C6P73_RS21365 4031207..4032025 - 819 WP_001234620.1 DUF945 domain-containing protein -
C6P73_RS21375 4032125..4032358 - 234 WP_001119729.1 DUF905 family protein -
C6P73_RS21380 4032437..4032778 - 342 WP_072097794.1 hypothetical protein -
C6P73_RS21385 4032867..4033271 + 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
C6P73_RS21390 4033268..4033615 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T98504 WP_000854757.1 NZ_CP027387:c4029264-4028887 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T98504 NZ_CP027387:c4029264-4028887 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT98504 WP_001295723.1 NZ_CP027387:c4029722-4029354 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT98504 NZ_CP027387:c4029722-4029354 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References