98453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 63389..63936 Replicon plasmid unnamed1
Accession NZ_CP027374
Organism Escherichia coli strain 05-3629

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag C6P66_RS25775 Protein ID WP_000969996.1
Coordinates 63655..63936 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A2W8GN83
Locus tag C6P66_RS25770 Protein ID WP_000079940.1
Coordinates 63389..63658 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6P66_RS25720 59034..59567 - 534 WP_001303319.1 transcription termination factor NusG -
C6P66_RS25730 60009..60296 - 288 WP_000074849.1 conjugal transfer protein TraA -
C6P66_RS25735 60214..60477 - 264 WP_001324596.1 ash family protein -
C6P66_RS25750 61448..62479 + 1032 WP_022630251.1 replication initiation protein -
C6P66_RS25770 63389..63658 + 270 WP_000079940.1 hypothetical protein Antitoxin
C6P66_RS25775 63655..63936 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6P66_RS25780 64136..64402 - 267 WP_000627828.1 hypothetical protein -
C6P66_RS25785 64402..64896 - 495 WP_106916384.1 hypothetical protein -
C6P66_RS25790 64952..65554 - 603 WP_021561689.1 hypothetical protein -
C6P66_RS25795 65663..65839 + 177 Protein_63 hypothetical protein -
C6P66_RS25800 65861..66196 - 336 WP_001080730.1 colicin 1A immunity protein -
C6P66_RS25810 66325..66672 + 348 WP_044704890.1 hypothetical protein -
C6P66_RS25815 66690..67280 - 591 WP_000198612.1 hypothetical protein -
C6P66_RS25820 67280..67537 - 258 WP_000343101.1 hypothetical protein -
C6P66_RS25825 68107..68520 + 414 WP_000465045.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91648 91648


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T98453 WP_000969996.1 NZ_CP027374:63655-63936 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T98453 NZ_CP027374:63655-63936 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCTTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCAGTGGGGGAAAGTG
TATATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10274.60 Da        Isoelectric Point: 7.2057

>AT98453 WP_000079940.1 NZ_CP027374:63389-63658 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDMLSHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT98453 NZ_CP027374:63389-63658 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGTCGTCAGCAACTCGAACGCGGTGATATGCTTTCCCATGACATGGTCGAATCTTCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A2W8GN83

References