Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 1010244..1010933 Replicon chromosome
Accession NZ_CP027373
Organism Escherichia coli strain 05-3629

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag C6P66_RS05390 Protein ID WP_001460496.1
Coordinates 1010244..1010582 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag C6P66_RS05395 Protein ID WP_001460495.1
Coordinates 1010607..1010933 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6P66_RS05370 1005334..1007532 + 2199 WP_106916210.1 aldehyde oxidoreductase molybdenum-binding subunit PaoC -
C6P66_RS05375 1007542..1008498 + 957 WP_000121356.1 molybdenum cofactor insertion chaperone PaoD -
C6P66_RS05380 1008549..1008887 + 339 Protein_969 LysR family transcriptional regulator -
C6P66_RS05385 1009246..1010097 - 852 WP_097447682.1 hypothetical protein -
C6P66_RS05390 1010244..1010582 - 339 WP_001460496.1 TA system toxin CbtA family protein Toxin
C6P66_RS05395 1010607..1010933 - 327 WP_001460495.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C6P66_RS05400 1010976..1011455 - 480 WP_097447683.1 DNA repair protein RadC -
C6P66_RS05405 1011468..1011914 - 447 WP_050561233.1 antirestriction protein -
C6P66_RS05410 1011993..1012811 - 819 WP_097447684.1 DUF945 domain-containing protein -
C6P66_RS05415 1013274..1013897 + 624 WP_001461983.1 inovirus Gp2 family protein -
C6P66_RS05420 1014016..1014231 + 216 WP_001461982.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagW/ecpD / yagV/ecpE 982692..1025297 42605


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12771.67 Da        Isoelectric Point: 8.5253

>T98427 WP_001460496.1 NZ_CP027373:c1010582-1010244 [Escherichia coli]
MKTLPANQRVAKPCPPPVLVWQTLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGFN
CQEQSPYLRAVDILRARQATGLLRQSHHPSAR

Download         Length: 339 bp

>T98427 NZ_CP027373:c1010582-1010244 [Escherichia coli]
ATGAAAACTCTTCCTGCAAATCAGCGGGTGGCGAAGCCATGCCCGCCGCCTGTACTTGTCTGGCAAACGCTACTTACACG
TCTGCTGGAGCAACACTATGGTCTGACGCTGAACGACACGCCGTTCAGTGATGAAACCGTTATTCAGGAGCATATCAATG
CCGGTATTACGCTGGCTGATGCCGTTAACTTTCTGGTGGAAAAGTACGAACTGGTTCGAATCGATCGCAGAGGGTTTAAC
TGTCAGGAGCAGTCACCTTACCTTCGGGCGGTAGATATTTTACGGGCCCGACAGGCAACCGGCCTCTTGCGGCAAAGCCA
TCATCCTTCGGCACGCTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12552.27 Da        Isoelectric Point: 6.3682

>AT98427 WP_001460495.1 NZ_CP027373:c1010933-1010607 [Escherichia coli]
MEKHDTPEWGLRCDVMPRFSARLVQKNNRLHYLADRAGITGAFKEEECHQLNSAFPHFIEQMELMLLSGELNPRHAHRVT
LYHDELTCEADTLGSCGYVYMAIYPTQR

Download         Length: 327 bp

>AT98427 NZ_CP027373:c1010933-1010607 [Escherichia coli]
ATGGAAAAACACGATACCCCTGAATGGGGCCTTCGGTGTGATGTAATGCCTCGCTTTAGTGCAAGGCTGGTACAGAAAAA
CAACCGGCTGCATTATTTAGCTGATCGCGCCGGGATAACTGGCGCTTTCAAAGAAGAAGAGTGCCACCAACTGAATAGCG
CATTTCCGCACTTTATAGAACAGATGGAATTGATGCTGCTTTCTGGTGAGCTTAACCCCCGCCATGCACACCGCGTCACT
CTGTACCATGACGAACTGACCTGTGAAGCGGATACACTTGGTAGCTGTGGCTACGTTTATATGGCGATTTATCCCACTCA
ACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References