Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 110941..111412 | Replicon | chromosome |
Accession | NZ_CP027373 | ||
Organism | Escherichia coli strain 05-3629 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
Locus tag | C6P66_RS00735 | Protein ID | WP_001303511.1 |
Coordinates | 111134..111412 (+) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | Q8XAD5 |
Locus tag | C6P66_RS00730 | Protein ID | WP_001302048.1 |
Coordinates | 110941..111132 (+) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C6P66_RS27080 | 106309..106485 | - | 177 | WP_000753060.1 | hypothetical protein | - |
C6P66_RS00685 | 106478..106660 | - | 183 | WP_032284905.1 | hypothetical protein | - |
C6P66_RS00690 | 106808..107113 | - | 306 | WP_072095369.1 | DUF4406 domain-containing protein | - |
C6P66_RS00695 | 107110..107391 | - | 282 | WP_072094476.1 | DNA-binding protein | - |
C6P66_RS00700 | 107424..108140 | - | 717 | WP_050877165.1 | DUF1627 domain-containing protein | - |
C6P66_RS00705 | 108174..108716 | - | 543 | WP_072130322.1 | replication protein | - |
C6P66_RS26845 | 108628..109659 | - | 1032 | WP_028985607.1 | phage replisome organiser | - |
C6P66_RS00715 | 109728..110153 | - | 426 | WP_000693925.1 | Rha family transcriptional regulator | - |
C6P66_RS00720 | 110150..110452 | - | 303 | WP_032279888.1 | transcriptional regulator | - |
C6P66_RS00725 | 110549..110920 | + | 372 | WP_001169685.1 | hypothetical protein | - |
C6P66_RS00730 | 110941..111132 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
C6P66_RS00735 | 111134..111412 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
C6P66_RS00740 | 111703..111855 | + | 153 | WP_000367379.1 | DUF1391 family protein | - |
C6P66_RS00745 | 111969..112484 | - | 516 | WP_032284904.1 | hypothetical protein | - |
C6P66_RS00760 | 113013..113201 | + | 189 | WP_000450222.1 | cell division inhibitor | - |
C6P66_RS00765 | 113198..113386 | + | 189 | WP_000092784.1 | DUF1482 family protein | - |
C6P66_RS00770 | 113479..115923 | + | 2445 | WP_032284903.1 | exonuclease | - |
C6P66_RS00775 | 115985..116254 | + | 270 | WP_000003742.1 | excisionase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | stx2B / stx2A | 53196..124510 | 71314 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T98425 WP_001303511.1 NZ_CP027373:111134-111412 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T98425 NZ_CP027373:111134-111412 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCAGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTGGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCAGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTGGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT98425 WP_001302048.1 NZ_CP027373:110941-111132 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT98425 NZ_CP027373:110941-111132 [Escherichia coli]
ATGAATAGAGCCCTTTCACCGATGGTTTCTGAGTTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCGATGGTTTCTGAGTTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 5CZF | |
PDB | 5CW7 | |
PDB | 5CZE |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CTP0 |