Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4672209..4673044 | Replicon | chromosome |
| Accession | NZ_CP027361 | ||
| Organism | Escherichia coli strain 2014C-4639 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A136X5A2 |
| Locus tag | RR62_RS23820 | Protein ID | WP_000854757.1 |
| Coordinates | 4672667..4673044 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | RR62_RS23815 | Protein ID | WP_001295723.1 |
| Coordinates | 4672209..4672577 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RR62_RS23775 (4668316) | 4668316..4668663 | - | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| RR62_RS23780 (4668660) | 4668660..4669064 | - | 405 | WP_000839179.1 | transposase | - |
| RR62_RS23785 (4669144) | 4669144..4669494 | + | 351 | Protein_4618 | IrmA family protein | - |
| RR62_RS23790 (4669573) | 4669573..4669806 | + | 234 | WP_001119729.1 | DUF905 family protein | - |
| RR62_RS23795 (4669906) | 4669906..4670724 | + | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| RR62_RS23800 (4670779) | 4670779..4671264 | + | 486 | WP_000849582.1 | antirestriction protein | - |
| RR62_RS23805 (4671280) | 4671280..4671756 | + | 477 | WP_001186725.1 | RadC family protein | - |
| RR62_RS23810 (4671825) | 4671825..4672046 | + | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| RR62_RS23815 (4672209) | 4672209..4672577 | + | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| RR62_RS23820 (4672667) | 4672667..4673044 | + | 378 | WP_000854757.1 | TA system toxin CbtA family protein | Toxin |
| RR62_RS23825 (4673041) | 4673041..4673190 | + | 150 | Protein_4626 | DUF5983 family protein | - |
| RR62_RS23830 (4673290) | 4673290..4673370 | + | 81 | Protein_4627 | hypothetical protein | - |
| RR62_RS23835 (4674186) | 4674186..4674557 | + | 372 | WP_001295631.1 | IS110 family transposase | - |
| RR62_RS27395 (4674828) | 4674828..4675193 | + | 366 | WP_001282181.1 | EutP/PduV family microcompartment system protein | - |
| RR62_RS23845 (4675294) | 4675294..4675623 | - | 330 | WP_000450409.1 | DUF496 family protein | - |
| RR62_RS23850 (4675795) | 4675795..4676853 | - | 1059 | WP_001200887.1 | FUSC family protein | - |
| RR62_RS23855 (4677051) | 4677051..4677524 | - | 474 | WP_001105384.1 | DNA gyrase inhibitor SbmC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14153.18 Da Isoelectric Point: 7.3249
>T98320 WP_000854757.1 NZ_CP027361:4672667-4673044 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T98320 NZ_CP027361:4672667-4673044 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT98320 WP_001295723.1 NZ_CP027361:4672209-4672577 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT98320 NZ_CP027361:4672209-4672577 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A136X5A2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1NM52 |