Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 4269108..4269634 | Replicon | chromosome |
| Accession | NZ_CP027361 | ||
| Organism | Escherichia coli strain 2014C-4639 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | RR62_RS21545 | Protein ID | WP_000323025.1 |
| Coordinates | 4269108..4269395 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | RR62_RS21550 | Protein ID | WP_000534858.1 |
| Coordinates | 4269395..4269634 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RR62_RS21495 (4264132) | 4264132..4264347 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| RR62_RS21500 (4264567) | 4264567..4264737 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| RR62_RS21505 (4265101) | 4265101..4265316 | - | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| RR62_RS21510 (4265617) | 4265617..4265829 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| RR62_RS21515 (4265884) | 4265884..4265973 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| RR62_RS21520 (4266251) | 4266251..4267003 | - | 753 | WP_001047133.1 | antitermination protein | - |
| RR62_RS21525 (4267017) | 4267017..4268066 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| RR62_RS21530 (4268068) | 4268068..4268346 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| RR62_RS21535 (4268413) | 4268413..4268664 | - | 252 | WP_000980994.1 | protein Rem | - |
| RR62_RS21540 (4268881) | 4268881..4269036 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| RR62_RS21545 (4269108) | 4269108..4269395 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| RR62_RS21550 (4269395) | 4269395..4269634 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| RR62_RS21555 (4269659) | 4269659..4269964 | + | 306 | WP_001326990.1 | protein YdfV | - |
| RR62_RS21560 (4270167) | 4270167..4270499 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| RR62_RS27330 (4270936) | 4270936..4271085 | - | 150 | WP_180302674.1 | protein YdfW | - |
| RR62_RS21565 (4271158) | 4271158..4272255 | - | 1098 | Protein_4177 | ISNCY family transposase | - |
| RR62_RS21570 (4272310) | 4272310..4272729 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| RR62_RS21575 (4272770) | 4272770..4273735 | - | 966 | WP_000054507.1 | hypothetical protein | - |
| RR62_RS21580 (4273716) | 4273716..4274237 | - | 522 | WP_000705349.1 | toxin YdaT family protein | - |
| RR62_RS21585 (4274221) | 4274221..4274448 | - | 228 | WP_000476993.1 | Cro/CI family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | stxB / stxA | 4233782..4333539 | 99757 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T98307 WP_000323025.1 NZ_CP027361:c4269395-4269108 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T98307 NZ_CP027361:c4269395-4269108 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT98307 WP_000534858.1 NZ_CP027361:c4269634-4269395 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT98307 NZ_CP027361:c4269634-4269395 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|