Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3586931..3587726 Replicon chromosome
Accession NZ_CP027361
Organism Escherichia coli strain 2014C-4639

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag RR62_RS17885 Protein ID WP_000854914.1
Coordinates 3587352..3587726 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag RR62_RS17880 Protein ID WP_001280953.1
Coordinates 3586931..3587305 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RR62_RS17850 (3582286) 3582286..3583191 + 906 WP_000203541.1 diguanylate cyclase regulator RdcB family protein -
RR62_RS17855 (3583188) 3583188..3584258 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
RR62_RS17860 (3584598) 3584598..3585416 + 819 WP_001234682.1 DUF932 domain-containing protein -
RR62_RS17865 (3585507) 3585507..3585992 + 486 WP_000214398.1 antirestriction protein -
RR62_RS17870 (3586008) 3586008..3586484 + 477 WP_001186738.1 RadC family protein -
RR62_RS17875 (3586547) 3586547..3586768 + 222 WP_000692323.1 DUF987 domain-containing protein -
RR62_RS17880 (3586931) 3586931..3587305 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
RR62_RS17885 (3587352) 3587352..3587726 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
RR62_RS17890 (3587723) 3587723..3588214 + 492 WP_000976857.1 DUF5983 family protein -
RR62_RS17895 (3588226) 3588226..3588423 + 198 WP_000839282.1 DUF957 domain-containing protein -
RR62_RS17900 (3588508) 3588508..3589350 + 843 WP_001280481.1 DUF4942 domain-containing protein -
RR62_RS17910 (3589821) 3589821..3590759 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
RR62_RS17915 (3590814) 3590814..3591551 + 738 WP_000283664.1 zinc-binding phosphatase -
RR62_RS17920 (3591575) 3591575..3592129 + 555 WP_001001902.1 molecular chaperone YcdY -
RR62_RS17925 (3592231) 3592231..3592722 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 3575191..3598287 23096


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T98298 WP_000854914.1 NZ_CP027361:3587352-3587726 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T98298 NZ_CP027361:3587352-3587726 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT98298 WP_001280953.1 NZ_CP027361:3586931-3587305 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT98298 NZ_CP027361:3586931-3587305 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References