Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3378697..3379175 Replicon chromosome
Accession NZ_CP027361
Organism Escherichia coli strain 2014C-4639

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag RR62_RS16630 Protein ID WP_001303876.1
Coordinates 3378697..3378984 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag RR62_RS16635 Protein ID WP_000536233.1
Coordinates 3378984..3379175 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RR62_RS16600 (3373920) 3373920..3376370 - 2451 WP_000048583.1 exonuclease -
RR62_RS16605 (3376464) 3376464..3376655 - 192 WP_001098307.1 DUF1482 family protein -
RR62_RS16610 (3376652) 3376652..3376840 - 189 WP_000413705.1 cell division inhibition protein DicB -
RR62_RS16615 (3377408) 3377408..3377617 + 210 WP_001133037.1 hypothetical protein -
RR62_RS16620 (3377618) 3377618..3378256 - 639 WP_000394543.1 hypothetical protein -
RR62_RS16625 (3378268) 3378268..3378420 - 153 WP_000380316.1 DUF1391 family protein -
RR62_RS16630 (3378697) 3378697..3378984 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RR62_RS16635 (3378984) 3378984..3379175 - 192 WP_000536233.1 hypothetical protein Antitoxin
RR62_RS16640 (3379203) 3379203..3379604 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
RR62_RS16645 (3379713) 3379713..3379985 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
RR62_RS16650 (3379969) 3379969..3380394 + 426 WP_000693855.1 toxin YdaT family protein -
RR62_RS16655 (3380601) 3380601..3381056 - 456 WP_000273724.1 hypothetical protein -
RR62_RS16660 (3381135) 3381135..3382250 + 1116 WP_001205821.1 hypothetical protein -
RR62_RS16665 (3382257) 3382257..3383003 + 747 WP_000788742.1 ATP-binding protein -
RR62_RS16670 (3383025) 3383025..3383795 + 771 WP_000451007.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3365257..3385702 20445


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T98297 WP_001303876.1 NZ_CP027361:c3378984-3378697 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T98297 NZ_CP027361:c3378984-3378697 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT98297 WP_000536233.1 NZ_CP027361:c3379175-3378984 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT98297 NZ_CP027361:c3379175-3378984 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References