Detailed information of TA system TA098278

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 45431..45978
• Replicon: plasmid unnamed2
• Accession: NZ_CP027357
• Organism: Escherichia coli strain 2013C-4991

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: C6P55_RS29460
• Protein ID: WP_000969990.1
• Coordinates: 45431..45712 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: E1QMW3
• Locus tag: C6P55_RS29465
• Protein ID: WP_000079941.1
• Coordinates: 45709..45978 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6P55_RS29430	41697..42730	-	1034	Protein_39	3-deoxy-7-phosphoheptulonate synthase	-
C6P55_RS29440	43289..43636	-	348	WP_000142437.1	hypothetical protein	-
C6P55_RS29450	43938..44420	-	483	WP_001311056.1	hypothetical protein	-
C6P55_RS29455	44537..45385	-	849	WP_106912714.1	3'-5' exonuclease	-
C6P55_RS29460	45431..45712	-	282	WP_000969990.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C6P55_RS29465	45709..45978	-	270	WP_000079941.1	hypothetical protein	Antitoxin
C6P55_RS29470	46500..47736	+	1237	Protein_45	IS3 family transposase	-
C6P55_RS29480	48959..50152	+	1194	WP_000450494.1	GTP-binding protein	-
C6P55_RS29485	50330..50479	+	150	Protein_47	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	tet(A) / sitABCD	iroB / iroC / iroD / iroE / iroN / iroN	1..131463	131463

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10930.61 Da
• Isoelectric Point: 8.4615

>T98278 WP_000969990.1 NZ_CP027357:c45712-45431 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASNLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTVQKWP

Nucleotide

• Length: 282 bp

>T98278 NZ_CP027357:c45712-45431 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAACCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGAGTATTGCATACTGTACAGAAGTGGCCATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10252.58 Da
• Isoelectric Point: 7.2057

>AT98278 WP_000079941.1 NZ_CP027357:c45978-45709 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Nucleotide

• Length: 270 bp

>AT98278 NZ_CP027357:c45978-45709 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTACTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A629TXC5