Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 49321..49856 Replicon plasmid unnamed1
Accession NZ_CP027356
Organism Escherichia coli strain 2013C-4991

Toxin (Protein)


Gene name relE Uniprot ID T2HS21
Locus tag C6P55_RS29005 Protein ID WP_000222775.1
Coordinates 49569..49856 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T2HSA2
Locus tag C6P55_RS29000 Protein ID WP_001139207.1
Coordinates 49321..49572 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6P55_RS28955 44558..44917 - 360 Protein_43 DUF1449 family protein -
C6P55_RS28965 45184..45849 - 666 WP_000154135.1 hypothetical protein -
C6P55_RS28970 45990..46631 - 642 WP_000335839.1 transcription termination factor NusG -
C6P55_RS28985 47340..48371 + 1032 WP_000907857.1 replication initiation protein -
C6P55_RS31295 49067..49234 + 168 WP_000841010.1 hypothetical protein -
C6P55_RS29000 49321..49572 + 252 WP_001139207.1 plasmid stabilization protein Antitoxin
C6P55_RS29005 49569..49856 + 288 WP_000222775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6P55_RS29010 49866..50412 + 547 Protein_50 hypothetical protein -
C6P55_RS29030 51064..51666 - 603 WP_000517689.1 hypothetical protein -
C6P55_RS29040 52020..53366 + 1347 WP_001132021.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - espP / hlyC / hlyA / hlyB / hlyB / hlyD 1..71714 71714


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11142.17 Da        Isoelectric Point: 10.6261

>T98276 WP_000222775.1 NZ_CP027356:49569-49856 [Escherichia coli]
MTYTVKFRDDALREWLKLDKSVQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

>T98276 NZ_CP027356:49569-49856 [Escherichia coli]
ATGACTTATACGGTTAAATTCAGGGATGATGCCCTCAGGGAATGGCTGAAACTGGATAAATCCGTTCAACAACAGTTCGC
AAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCTTCAGCAAAACTACGTGGATTAAAAGATTGCTACAAAATAA
AACTTCGCGCATCAGGTTTTCGTCTGGTCTATCAGGTGATTGATGACATGTTAATTATTGCGGTTGTCGCAGTAGGTAAA
CGTGAACGTAGTCATGTTTACAATCTCGCCAGCGAGAGAATGAGATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9216.45 Da        Isoelectric Point: 4.0927

>AT98276 WP_001139207.1 NZ_CP027356:49321-49572 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDAMDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT98276 NZ_CP027356:49321-49572 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGCGTCAGTGAACTGAAAAAAAATCCAATGGCGACAGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCTGCATTCTACTGTGTTCCTGCTGAATTGTATGAAAGGATGC
TTGATGCTATGGATGACCAGGAGCTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTACATGATGTGGACCTGGAT
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T2HS21

Antitoxin

Source ID Structure
AlphaFold DB A0A754EQ65

References