Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4630074..4630872 Replicon chromosome
Accession NZ_CP027355
Organism Escherichia coli strain 2013C-4991

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag C6P55_RS24785 Protein ID WP_000854735.1
Coordinates 4630074..4630451 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag C6P55_RS24790 Protein ID WP_001285415.1
Coordinates 4630498..4630872 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6P55_RS24750 4625305..4625925 + 621 Protein_4500 IS66-like element ISEc8 family transposase -
C6P55_RS24755 4626042..4627307 - 1266 WP_025380679.1 integrase arm-type DNA-binding domain-containing protein -
C6P55_RS24760 4627771..4628097 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
C6P55_RS24765 4628094..4628357 - 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
C6P55_RS24770 4628429..4629295 - 867 WP_001280433.1 DUF4942 domain-containing protein -
C6P55_RS24775 4629380..4629577 - 198 WP_000839291.1 DUF957 domain-containing protein -
C6P55_RS24780 4629589..4630077 - 489 WP_000761677.1 hypothetical protein -
C6P55_RS24785 4630074..4630451 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
C6P55_RS24790 4630498..4630872 - 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C6P55_RS24795 4630952..4631173 - 222 WP_000692309.1 DUF987 domain-containing protein -
C6P55_RS24800 4631236..4631712 - 477 WP_001366855.1 RadC family protein -
C6P55_RS24805 4631728..4632207 - 480 WP_000844100.1 antirestriction protein -
C6P55_RS24810 4632289..4633107 - 819 WP_001175148.1 DUF945 domain-containing protein -
C6P55_RS24815 4633197..4633430 - 234 WP_001278287.1 DUF905 family protein -
C6P55_RS24820 4633436..4634113 - 678 WP_001562086.1 hypothetical protein -
C6P55_RS24825 4634232..4635116 - 885 WP_000010403.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T98272 WP_000854735.1 NZ_CP027355:c4630451-4630074 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T98272 NZ_CP027355:c4630451-4630074 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT98272 WP_001285415.1 NZ_CP027355:c4630872-4630498 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT98272 NZ_CP027355:c4630872-4630498 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References