Detailed information of TA system TA098263

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1671792..1672636
• Replicon: chromosome
• Accession: NZ_CP027355
• Organism: Escherichia coli strain 2013C-4991

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LJY4
• Locus tag: C6P55_RS09490
• Protein ID: WP_000854686.1
• Coordinates: 1671792..1672175 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0J1S3
• Locus tag: C6P55_RS09495
• Protein ID: WP_001285602.1
• Coordinates: 1672256..1672636 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6P55_RS09450	1666795..1667286	-	492	WP_001300785.1	DUF1097 domain-containing protein	-
C6P55_RS09455	1667388..1667942	-	555	WP_001001902.1	molecular chaperone YcdY	-
C6P55_RS09460	1667966..1668703	-	738	WP_000283664.1	zinc-binding phosphatase	-
C6P55_RS09465	1668758..1669696	-	939	WP_000351315.1	glyoxylate/hydroxypyruvate reductase GhrA	-
C6P55_RS09475	1670166..1671008	-	843	WP_001431817.1	DUF4942 domain-containing protein	-
C6P55_RS09480	1671093..1671290	-	198	WP_000839253.1	DUF957 domain-containing protein	-
C6P55_RS09485	1671307..1671795	-	489	WP_001054233.1	hypothetical protein	-
C6P55_RS09490	1671792..1672175	-	384	WP_000854686.1	TA system toxin CbtA family protein	Toxin
C6P55_RS09495	1672256..1672636	-	381	WP_001285602.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
C6P55_RS09500	1672647..1673330	-	684	WP_000086768.1	hypothetical protein	-
C6P55_RS09505	1673349..1673570	-	222	WP_000692298.1	DUF987 domain-containing protein	-
C6P55_RS09510	1673633..1674109	-	477	WP_001186773.1	RadC family protein	-
C6P55_RS09515	1674125..1674610	-	486	WP_000214307.1	antirestriction protein	-
C6P55_RS09520	1674702..1675520	-	819	WP_001234732.1	DUF945 domain-containing protein	-
C6P55_RS09530	1675620..1675853	-	234	WP_001119717.1	DUF905 family protein	-
C6P55_RS09535	1675932..1676386	-	455	Protein_1744	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14272.28 Da
• Isoelectric Point: 6.8614

>T98263 WP_000854686.1 NZ_CP027355:c1672175-1671792 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Nucleotide

• Length: 384 bp

>T98263 NZ_CP027355:c1672175-1671792 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13938.69 Da
• Isoelectric Point: 5.0823

>AT98263 WP_001285602.1 NZ_CP027355:c1672636-1672256 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT98263 NZ_CP027355:c1672636-1672256 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG