Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1577567..1578048 Replicon chromosome
Accession NZ_CP027355
Organism Escherichia coli strain 2013C-4991

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7YS45
Locus tag C6P55_RS08935 Protein ID WP_014966210.1
Coordinates 1577758..1578048 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A0D7Y007
Locus tag C6P55_RS08930 Protein ID WP_000100896.1
Coordinates 1577567..1577758 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6P55_RS08895 1572598..1573233 - 636 Protein_1627 DUF1627 domain-containing protein -
C6P55_RS08900 1573287..1574500 + 1214 WP_162830753.1 IS3 family transposase -
C6P55_RS08905 1574715..1575257 - 543 WP_072130322.1 replication protein -
C6P55_RS30900 1575169..1576185 - 1017 WP_001262344.1 hypothetical protein -
C6P55_RS08915 1576257..1576682 - 426 WP_000693918.1 Rha family transcriptional regulator -
C6P55_RS08920 1576666..1576941 - 276 WP_001048458.1 helix-turn-helix domain-containing protein -
C6P55_RS08925 1577049..1577549 + 501 WP_000824162.1 helix-turn-helix transcriptional regulator -
C6P55_RS08930 1577567..1577758 + 192 WP_000100896.1 hypothetical protein Antitoxin
C6P55_RS08935 1577758..1578048 + 291 WP_014966210.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6P55_RS08940 1578318..1578473 + 156 WP_000379581.1 DUF1391 family protein -
C6P55_RS08950 1578633..1578851 + 219 WP_001171975.1 hypothetical protein -
C6P55_RS08960 1579419..1579607 + 189 WP_000449192.1 cell division inhibition protein DicB -
C6P55_RS08965 1579604..1579795 + 192 WP_001090200.1 DUF1482 family protein -
C6P55_RS08970 1579888..1582359 + 2472 WP_106912665.1 exonuclease -
C6P55_RS08975 1582421..1582690 + 270 WP_000003742.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - espM2 / espW 1521753..1590943 69190


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11176.05 Da        Isoelectric Point: 9.9854

>T98262 WP_014966210.1 NZ_CP027355:1577758-1578048 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKTC

Download         Length: 291 bp

>T98262 NZ_CP027355:1577758-1578048 [Escherichia coli]
ATGCTGCCCATTTTATGGCTACCTTCTGCACGTGATGATTTACGTCAGATCGTAGCCTATATTGCTAAGGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTACTGAACACCCTTATCTGTACCCACCGAGCG
AAAGAGTTCCAAGTCTTCGTGAGATAGTGACTCATCCTAACTACATAATACTTTACCGAGTAACAGCATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGACAGTATCCAAACAAAACCTGTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7033.83 Da        Isoelectric Point: 4.0270

>AT98262 WP_000100896.1 NZ_CP027355:1577567-1577758 [Escherichia coli]
MSTALSPIISEFETVEQENSYNEWLRTKVAASLSDPRPAIPHDEVMAEMENLIAQLAATNRSE

Download         Length: 192 bp

>AT98262 NZ_CP027355:1577567-1577758 [Escherichia coli]
ATGAGTACAGCCCTTTCCCCGATAATTTCTGAATTTGAAACAGTCGAACAAGAAAACAGCTATAACGAATGGTTGCGAAC
CAAAGTGGCAGCAAGCCTCTCAGATCCCCGTCCTGCAATTCCACATGACGAAGTAATGGCTGAAATGGAAAACCTTATTG
CTCAATTAGCTGCAACGAACAGGAGTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7YS45

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7Y007

References