Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 44569..45095 | Replicon | chromosome |
| Accession | NZ_CP027352 | ||
| Organism | Escherichia coli strain 2012C-4606 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | AYN42_RS00305 | Protein ID | WP_000323025.1 |
| Coordinates | 44808..45095 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | AYN42_RS00300 | Protein ID | WP_000534858.1 |
| Coordinates | 44569..44808 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AYN42_RS00265 | 39755..39982 | + | 228 | WP_000476993.1 | transcriptional regulator | - |
| AYN42_RS00270 | 39966..40487 | + | 522 | WP_000705349.1 | hypothetical protein | - |
| AYN42_RS00275 | 40468..41433 | + | 966 | WP_000054507.1 | hypothetical protein | - |
| AYN42_RS00280 | 41474..41893 | + | 420 | WP_001151195.1 | DUF977 family protein | - |
| AYN42_RS00285 | 41927..43267 | + | 1341 | WP_000589012.1 | ISNCY family transposase | - |
| AYN42_RS00290 | 43704..44036 | - | 333 | WP_001317460.1 | FlxA-like family protein | - |
| AYN42_RS00295 | 44239..44544 | - | 306 | WP_001326990.1 | hypothetical protein | - |
| AYN42_RS00300 | 44569..44808 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| AYN42_RS00305 | 44808..45095 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| AYN42_RS00310 | 45167..45322 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| AYN42_RS00315 | 45539..45790 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| AYN42_RS00320 | 45857..46135 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| AYN42_RS00325 | 46137..47186 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| AYN42_RS00330 | 47200..47952 | + | 753 | WP_001047133.1 | antitermination protein | - |
| AYN42_RS31090 | 48230..48319 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| AYN42_RS00335 | 48374..48586 | - | 213 | WP_106875218.1 | cold shock-like protein CspF | - |
| AYN42_RS00340 | 48887..49102 | + | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| AYN42_RS31735 | 49466..49636 | - | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| AYN42_RS00345 | 49856..50071 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleC | 83..88939 | 88856 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T98219 WP_000323025.1 NZ_CP027352:44808-45095 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T98219 NZ_CP027352:44808-45095 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT98219 WP_000534858.1 NZ_CP027352:44569-44808 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT98219 NZ_CP027352:44569-44808 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|