98156

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 905383..905854 Replicon chromosome
Accession NZ_CP027347
Organism Escherichia coli strain 2013C-4361

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag AZF34_RS04905 Protein ID WP_001303511.1
Coordinates 905383..905661 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag AZF34_RS04910 Protein ID WP_001302048.1
Coordinates 905663..905854 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AZF34_RS04870 902128..903486 - 1359 WP_106888368.1 exonuclease -
AZF34_RS04875 903579..903770 - 192 WP_001090200.1 DUF1482 family protein -
AZF34_RS04880 903767..903955 - 189 WP_000449192.1 cell division inhibition protein DicB -
AZF34_RS04890 904439..904657 - 219 WP_001171930.1 hypothetical protein -
AZF34_RS04895 904698..905087 - 390 WP_001447517.1 hypothetical protein -
AZF34_RS04905 905383..905661 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AZF34_RS04910 905663..905854 - 192 WP_001302048.1 hypothetical protein Antitoxin
AZF34_RS04915 905875..906246 - 372 WP_001169687.1 hypothetical protein -
AZF34_RS04920 906344..906646 + 303 WP_001444689.1 transcriptional regulator -
AZF34_RS04925 906643..907068 + 426 WP_000693943.1 Rha family transcriptional regulator -
AZF34_RS04930 907091..908053 + 963 WP_000095671.1 helix-turn-helix domain-containing protein -
AZF34_RS04935 908094..908516 + 423 WP_001151120.1 DUF977 family protein -
AZF34_RS04940 908513..908767 + 255 WP_032272537.1 hypothetical protein -
AZF34_RS04945 908760..909071 + 312 WP_001002672.1 hypothetical protein -
AZF34_RS04950 909377..909955 + 579 WP_001204666.1 sce7726 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - espX7/nleL / espX7/nleL / espN 898289..953261 54972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T98156 WP_001303511.1 NZ_CP027347:c905661-905383 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T98156 NZ_CP027347:c905661-905383 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT98156 WP_001302048.1 NZ_CP027347:c905854-905663 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT98156 NZ_CP027347:c905854-905663 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
AlphaFold DB A0A829CTP0

References