Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1548666..1549452 | Replicon | chromosome |
| Accession | NZ_CP027342 | ||
| Organism | Escherichia coli strain 2014C-4587 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A1M0ZYM8 |
| Locus tag | C6N23_RS07905 | Protein ID | WP_000854904.1 |
| Coordinates | 1548666..1549043 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | C6N23_RS07910 | Protein ID | WP_024210899.1 |
| Coordinates | 1549090..1549452 (-) | Length | 121 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C6N23_RS07875 | 1544012..1544989 | + | 978 | WP_000633238.1 | type II secretion system minor pseudopilin GspK | - |
| C6N23_RS07880 | 1544986..1546164 | + | 1179 | WP_032283517.1 | type II secretion system protein GspL | - |
| C6N23_RS07885 | 1546166..1546702 | + | 537 | WP_000942786.1 | GspM family type II secretion system protein YghD | - |
| C6N23_RS07890 | 1547045..1547887 | - | 843 | WP_001280537.1 | DUF4942 domain-containing protein | - |
| C6N23_RS07895 | 1547972..1548169 | - | 198 | WP_000839249.1 | DUF957 domain-containing protein | - |
| C6N23_RS07900 | 1548181..1548669 | - | 489 | WP_000779174.1 | hypothetical protein | - |
| C6N23_RS07905 | 1548666..1549043 | - | 378 | WP_000854904.1 | TA system toxin CbtA family protein | Toxin |
| C6N23_RS07910 | 1549090..1549452 | - | 363 | WP_024210899.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| C6N23_RS07915 | 1549615..1549836 | - | 222 | WP_000692311.1 | DUF987 domain-containing protein | - |
| C6N23_RS07920 | 1549899..1550375 | - | 477 | WP_001186727.1 | RadC family protein | - |
| C6N23_RS07925 | 1550391..1550876 | - | 486 | WP_047086999.1 | antirestriction protein | - |
| C6N23_RS07930 | 1550931..1551749 | - | 819 | WP_001234620.1 | DUF945 domain-containing protein | - |
| C6N23_RS07940 | 1551849..1552082 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| C6N23_RS07945 | 1552161..1552616 | - | 456 | WP_000581504.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | rfaE / gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / espP | 1435275..1623108 | 187833 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14280.26 Da Isoelectric Point: 7.2922
>T98129 WP_000854904.1 NZ_CP027342:c1549043-1548666 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T98129 NZ_CP027342:c1549043-1548666 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 121 a.a. Molecular weight: 13289.00 Da Isoelectric Point: 6.6250
>AT98129 WP_024210899.1 NZ_CP027342:c1549452-1549090 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAQAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAQAPATTS
Download Length: 363 bp
>AT98129 NZ_CP027342:c1549452-1549090 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCACAGGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCACAGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|