Detailed information of TA system TA098108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 3455544..3456023
• Replicon: chromosome
• Accession: NZ_CP027340
• Organism: Escherichia coli strain 2015C-3121

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A234Y3J1
• Locus tag: C6N25_RS18550
• Protein ID: WP_001444087.1
• Coordinates: 3455544..3455831 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: A0A234Y267
• Locus tag: C6N25_RS18555
• Protein ID: WP_001090455.1
• Coordinates: 3455835..3456023 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6N25_RS18510	3450672..3450941	-	270	WP_000003742.1	excisionase	-
C6N25_RS18515	3451003..3453390	-	2388	WP_106888822.1	exonuclease	-
C6N25_RS18520	3453431..3453754	-	324	WP_044809962.1	hypothetical protein	-
C6N25_RS18525	3453870..3454094	-	225	WP_044809961.1	cell division protein FtsZ	-
C6N25_RS30435	3454662..3454916	+	255	WP_033801181.1	hypothetical protein	-
C6N25_RS18540	3454900..3455115	-	216	WP_033801180.1	hypothetical protein	-
C6N25_RS18545	3455117..3455272	-	156	WP_062873438.1	DUF1391 family protein	-
C6N25_RS18550	3455544..3455831	-	288	WP_001444087.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C6N25_RS18555	3455835..3456023	-	189	WP_001090455.1	hypothetical protein	Antitoxin
C6N25_RS18560	3456053..3456451	-	399	WP_000209117.1	helix-turn-helix domain-containing protein	-
C6N25_RS18565	3456568..3456846	+	279	WP_047654503.1	helix-turn-helix domain-containing protein	-
C6N25_RS18570	3456830..3457351	+	522	WP_106888823.1	hypothetical protein	-
C6N25_RS18575	3457332..3458297	+	966	WP_000054520.1	hypothetical protein	-
C6N25_RS18580	3458304..3459044	+	741	WP_106888824.1	ATP-binding protein	-
C6N25_RS18585	3459070..3459825	+	756	WP_106888825.1	DUF1627 domain-containing protein	-
C6N25_RS18590	3459847..3460071	+	225	WP_000702797.1	hypothetical protein	-
C6N25_RS18595	3460068..3460424	+	357	WP_106888826.1	eae-like protein	-
C6N25_RS18600	3460434..3460610	+	177	WP_106888827.1	hypothetical protein	-
C6N25_RS18605	3460607..3460918	+	312	WP_001273106.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	stx2A / stx2B	3448751..3505248	56497

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11014.71 Da
• Isoelectric Point: 6.2118

>T98108 WP_001444087.1 NZ_CP027340:c3455831-3455544 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVATLSIE
IVSVVHARRQFPKQN

Nucleotide

• Length: 288 bp

>T98108 NZ_CP027340:c3455831-3455544 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTGGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCAGAACGCTTATGGCAGCGATTAAGGGGGTGTGTGCTGCCGTTATCCGAACACCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCTCACCCTAACTATATAATTCTTTACCGTGTAGCCACTTTAAGCATTGAG
ATCGTGAGTGTAGTACACGCCAGACGCCAATTCCCTAAGCAGAACTAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 7249.25 Da
• Isoelectric Point: 8.6832

>AT98108 WP_001090455.1 NZ_CP027340:c3456023-3455835 [Escherichia coli]
MNTALSPMVSEFETIEQENSYNEWLRAKVAASLANPRPAIPHDEVERRMAERFAKMRKERSK

Nucleotide

• Length: 189 bp

>AT98108 NZ_CP027340:c3456023-3455835 [Escherichia coli]
ATGAATACGGCCCTTTCACCAATGGTTTCTGAGTTCGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAGCGAGCCTTGCAAATCCGCGCCCAGCAATTCCCCATGACGAGGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGTAAGTAG

Structures

Toxin

• AlphaFold DB: A0A234Y3J1

Antitoxin

• AlphaFold DB: A0A234Y267