Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1665784..1666582 | Replicon | chromosome |
| Accession | NZ_CP027340 | ||
| Organism | Escherichia coli strain 2015C-3121 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0P7PH46 |
| Locus tag | C6N25_RS08825 | Protein ID | WP_000854896.1 |
| Coordinates | 1665784..1666161 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A234XUW5 |
| Locus tag | C6N25_RS08830 | Protein ID | WP_024175300.1 |
| Coordinates | 1666208..1666582 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C6N25_RS08790 | 1661061..1662599 | - | 1539 | WP_001187182.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
| C6N25_RS08800 | 1663481..1663807 | - | 327 | WP_000779483.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| C6N25_RS08805 | 1663804..1664067 | - | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| C6N25_RS08810 | 1664139..1665005 | - | 867 | WP_000014511.1 | DUF4942 domain-containing protein | - |
| C6N25_RS08815 | 1665090..1665287 | - | 198 | WP_000839256.1 | DUF957 domain-containing protein | - |
| C6N25_RS08820 | 1665299..1665787 | - | 489 | WP_000761662.1 | hypothetical protein | - |
| C6N25_RS08825 | 1665784..1666161 | - | 378 | WP_000854896.1 | TA system toxin CbtA family protein | Toxin |
| C6N25_RS08830 | 1666208..1666582 | - | 375 | WP_024175300.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| C6N25_RS08835 | 1666745..1666966 | - | 222 | WP_000692358.1 | DUF987 domain-containing protein | - |
| C6N25_RS08840 | 1667029..1667505 | - | 477 | WP_001186727.1 | RadC family protein | - |
| C6N25_RS08845 | 1667521..1668006 | - | 486 | WP_000214386.1 | antirestriction protein | - |
| C6N25_RS08850 | 1668096..1668914 | - | 819 | WP_001234751.1 | DUF945 domain-containing protein | - |
| C6N25_RS08855 | 1669005..1669238 | - | 234 | WP_001117568.1 | DUF905 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1653572..1723666 | 70094 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14210.19 Da Isoelectric Point: 7.2920
>T98102 WP_000854896.1 NZ_CP027340:c1666161-1665784 [Escherichia coli]
MKTLSDTHVREASRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ
MKTLSDTHVREASRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ
Download Length: 378 bp
>T98102 NZ_CP027340:c1666161-1665784 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGCATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGAACTGACCAGCCAGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGCATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGAACTGACCAGCCAGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13664.42 Da Isoelectric Point: 6.4757
>AT98102 WP_024175300.1 NZ_CP027340:c1666582-1666208 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVKPCFGARLVQEGNRLHYLADRAGISGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHSVTLYAKGLTCEADTLGSCGYVYLTVYPTPATATTS
VSDKLSGITHPDDNHDRPWWGLPCTVKPCFGARLVQEGNRLHYLADRAGISGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHSVTLYAKGLTCEADTLGSCGYVYLTVYPTPATATTS
Download Length: 375 bp
>AT98102 NZ_CP027340:c1666582-1666208 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAA
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGCGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATTCCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGACTGTTTATCCGACACCGGCAACCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAA
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGCGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATTCCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGACTGTTTATCCGACACCGGCAACCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0P7PH46 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A234XUW5 |