Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4526653..4527248 Replicon chromosome
Accession NZ_CP027338
Organism Escherichia coli strain 2014C-3051

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag C6N28_RS24555 Protein ID WP_000239579.1
Coordinates 4526653..4527003 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag C6N28_RS24560 Protein ID WP_001223208.1
Coordinates 4526997..4527248 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6N28_RS24535 4522099..4523121 - 1023 WP_001296689.1 ABC transporter permease -
C6N28_RS24540 4523135..4524637 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
C6N28_RS24545 4524777..4525733 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
C6N28_RS24550 4526043..4526573 + 531 WP_000055075.1 inorganic diphosphatase -
C6N28_RS24555 4526653..4527003 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
C6N28_RS24560 4526997..4527248 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
C6N28_RS24565 4527460..4527801 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
C6N28_RS24570 4527804..4531583 - 3780 WP_000060926.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T98089 WP_000239579.1 NZ_CP027338:c4527003-4526653 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T98089 NZ_CP027338:c4527003-4526653 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT98089 WP_001223208.1 NZ_CP027338:c4527248-4526997 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT98089 NZ_CP027338:c4527248-4526997 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References