Detailed information of TA system TA098085

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3051156..3051810
• Replicon: chromosome
• Accession: NZ_CP027338
• Organism: Escherichia coli strain 2014C-3051

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: S1EEB2
• Locus tag: C6N28_RS16955
• Protein ID: WP_000244777.1
• Coordinates: 3051156..3051563 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: C6N28_RS16960
• Protein ID: WP_000354043.1
• Coordinates: 3051544..3051810 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6N28_RS16935	3047113..3048846	-	1734	WP_000813220.1	single-stranded-DNA-specific exonuclease RecJ	-
C6N28_RS16940	3048852..3049562	-	711	WP_000715214.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
C6N28_RS16945	3049587..3050483	-	897	WP_000806638.1	site-specific tyrosine recombinase XerD	-
C6N28_RS16950	3050595..3051116	+	522	WP_001055874.1	flavodoxin FldB	-
C6N28_RS16955	3051156..3051563	-	408	WP_000244777.1	toxin CptA	Toxin
C6N28_RS16960	3051544..3051810	-	267	WP_000354043.1	FAD assembly factor SdhE	Antitoxin
C6N28_RS16965	3052053..3053033	+	981	WP_000886095.1	tRNA-modifying protein YgfZ	-
C6N28_RS16970	3053229..3053888	-	660	WP_000250274.1	hemolysin III family protein	-
C6N28_RS16975	3054052..3054363	-	312	WP_001182954.1	N(4)-acetylcytidine aminohydrolase	-
C6N28_RS16980	3054408..3055841	+	1434	WP_001341859.1	6-phospho-beta-glucosidase BglA	-
C6N28_RS16985	3055898..3056641	-	744	WP_000951964.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 16031.96 Da
• Isoelectric Point: 11.5202

>T98085 WP_000244777.1 NZ_CP027338:c3051563-3051156 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Nucleotide

• Length: 408 bp

>T98085 NZ_CP027338:c3051563-3051156 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10563.16 Da
• Isoelectric Point: 5.1599

>AT98085 WP_000354043.1 NZ_CP027338:c3051810-3051544 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDLDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT98085 NZ_CP027338:c3051810-3051544 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCTGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A7U9LFV7