Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 631676..632154 Replicon chromosome
Accession NZ_CP027331
Organism Escherichia coli strain 2013C-3277

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag MJ63_RS03515 Protein ID WP_001303876.1
Coordinates 631676..631963 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag MJ63_RS03520 Protein ID WP_000536233.1
Coordinates 631963..632154 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ63_RS03475 626838..629309 - 2472 WP_000048520.1 exonuclease -
MJ63_RS03480 629402..629593 - 192 WP_001090200.1 DUF1482 family protein -
MJ63_RS03485 629590..629778 - 189 WP_000449192.1 cell division inhibition protein DicB -
MJ63_RS03495 630341..630526 + 186 WP_001133046.1 hypothetical protein -
MJ63_RS03500 630713..631102 - 390 WP_000394511.1 hypothetical protein -
MJ63_RS03510 631244..631399 - 156 WP_000379575.1 DUF1391 family protein -
MJ63_RS03515 631676..631963 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MJ63_RS03520 631963..632154 - 192 WP_000536233.1 hypothetical protein Antitoxin
MJ63_RS03525 632182..632583 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
MJ63_RS03530 632692..632964 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
MJ63_RS03535 632948..633373 + 426 WP_000693855.1 Rha family transcriptional regulator -
MJ63_RS03540 633579..634034 - 456 WP_000273724.1 hypothetical protein -
MJ63_RS03545 634113..635204 + 1092 WP_001205823.1 hypothetical protein -
MJ63_RS03550 635211..635957 + 747 WP_000788750.1 ATP-binding protein -
MJ63_RS03555 635979..636749 + 771 WP_000451007.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - espW / espM2 617384..693550 76166


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T98016 WP_001303876.1 NZ_CP027331:c631963-631676 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T98016 NZ_CP027331:c631963-631676 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT98016 WP_000536233.1 NZ_CP027331:c632154-631963 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT98016 NZ_CP027331:c632154-631963 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References