Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 694156..695144 Replicon chromosome
Accession NZ_CP027325
Organism Escherichia coli strain 2013C-4830

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag C6N65_RS03710 Protein ID WP_014640052.1
Coordinates 694156..694542 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A0A1AFM1
Locus tag C6N65_RS03715 Protein ID WP_000458583.1
Coordinates 694572..695144 (-) Length 191 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6N65_RS03675 689304..689975 - 672 Protein_659 serine/threonine protein phosphatase -
C6N65_RS03680 690032..691245 + 1214 WP_167588588.1 IS3 family transposase -
C6N65_RS03685 691289..692025 - 737 Protein_661 IS3 family transposase -
C6N65_RS03690 692146..692334 + 189 WP_001014286.1 hypothetical protein -
C6N65_RS03695 692337..693005 + 669 WP_047087994.1 DUF550 domain-containing protein -
C6N65_RS03700 693005..693577 + 573 WP_001061348.1 3'-5' exoribonuclease -
C6N65_RS03705 693614..693895 + 282 WP_001093921.1 pyocin activator PrtN family protein -
C6N65_RS28795 693943..694116 - 174 WP_000390069.1 hypothetical protein -
C6N65_RS03710 694156..694542 - 387 WP_014640052.1 hypothetical protein Toxin
C6N65_RS03715 694572..695144 - 573 WP_000458583.1 SocA family protein Antitoxin
C6N65_RS03720 695368..695502 - 135 WP_071887528.1 tRNA-dihydrouridine synthase -
C6N65_RS03725 695865..696850 - 986 Protein_670 DUF2713 domain-containing protein -
C6N65_RS03735 697168..697683 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
C6N65_RS03740 697725..697934 - 210 WP_001030593.1 CsbD family protein -
C6N65_RS03745 698050..699375 - 1326 WP_032206041.1 MATE family efflux transporter DinF -
C6N65_RS03750 699448..700056 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 656478..700056 43578


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(27-137)


Sequences


Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T97987 WP_014640052.1 NZ_CP027325:c694542-694156 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T97987 NZ_CP027325:c694542-694156 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGGGTCCCCCACGATCCGTCTTGCGTCTTGAATTCCGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 191 a.a.        Molecular weight: 21956.30 Da        Isoelectric Point: 6.0283

>AT97987 WP_000458583.1 NZ_CP027325:c695144-694572 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Download         Length: 573 bp

>AT97987 NZ_CP027325:c695144-694572 [Escherichia coli]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGCATTGGTGACTACTGGTACAAC
TTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAGTT
GAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATTTGATCTCGCAAACATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AFM1

References