Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4109990..4110791 Replicon chromosome
Accession NZ_CP027323
Organism Escherichia coli strain 2013C-3033

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H0JYG3
Locus tag C6N24_RS21855 Protein ID WP_001094432.1
Coordinates 4110414..4110791 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7NA60
Locus tag C6N24_RS21850 Protein ID WP_001380152.1
Coordinates 4109990..4110367 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6N24_RS21815 4106641..4107102 + 462 WP_000581501.1 hypothetical protein -
C6N24_RS30080 4107214..4107425 - 212 Protein_4018 hypothetical protein -
C6N24_RS21825 4107505..4108326 + 822 WP_001241714.1 DUF945 domain-containing protein -
C6N24_RS21830 4108326..4108526 + 201 WP_001367430.1 hypothetical protein -
C6N24_RS21835 4108660..4109133 + 474 WP_000855069.1 antirestriction protein -
C6N24_RS21840 4109148..4109624 + 477 WP_033884753.1 RadC family protein -
C6N24_RS21845 4109693..4109914 + 222 WP_064506879.1 DUF987 domain-containing protein -
C6N24_RS21850 4109990..4110367 + 378 WP_001380152.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
C6N24_RS21855 4110414..4110791 + 378 WP_001094432.1 TA system toxin CbtA family protein Toxin
C6N24_RS21860 4110788..4111276 + 489 WP_033884750.1 hypothetical protein -
C6N24_RS21865 4111288..4111485 + 198 WP_000839249.1 DUF957 domain-containing protein -
C6N24_RS21870 4111570..4112415 + 846 WP_001280530.1 DUF4942 domain-containing protein -
C6N24_RS21885 4113205..4114389 + 1185 WP_001172876.1 sugar efflux transporter -
C6N24_RS21890 4114500..4115423 + 924 WP_000535960.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14136.99 Da        Isoelectric Point: 6.4729

>T97976 WP_001094432.1 NZ_CP027323:4110414-4110791 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T97976 NZ_CP027323:4110414-4110791 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGTCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13679.52 Da        Isoelectric Point: 5.8682

>AT97976 WP_001380152.1 NZ_CP027323:4109990-4110367 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT97976 NZ_CP027323:4109990-4110367 [Escherichia coli]
GTGTCAGACACACTCCCCGGAACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTAGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0JYG3

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7NA60

References