Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 5039797..5040275 Replicon chromosome
Accession NZ_CP027317
Organism Escherichia coli strain 2015C-3107

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag C6N21_RS26380 Protein ID WP_001303876.1
Coordinates 5039797..5040084 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag C6N21_RS26385 Protein ID WP_000536233.1
Coordinates 5040084..5040275 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6N21_RS26340 5034948..5037419 - 2472 WP_000034468.1 exonuclease -
C6N21_RS26345 5037513..5037704 - 192 WP_001098307.1 DUF1482 family protein -
C6N21_RS26350 5037701..5037889 - 189 WP_000413705.1 cell division inhibition protein DicB -
C6N21_RS26360 5038463..5038648 + 186 WP_001133046.1 hypothetical protein -
C6N21_RS26365 5038835..5039224 - 390 WP_000394511.1 hypothetical protein -
C6N21_RS26375 5039366..5039521 - 156 WP_000379575.1 DUF1391 family protein -
C6N21_RS26380 5039797..5040084 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6N21_RS26385 5040084..5040275 - 192 WP_000536233.1 hypothetical protein Antitoxin
C6N21_RS26390 5040303..5040704 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
C6N21_RS26395 5040813..5041085 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
C6N21_RS26400 5041069..5041494 + 426 WP_000693855.1 Rha family transcriptional regulator -
C6N21_RS26405 5041701..5042156 - 456 WP_000273724.1 hypothetical protein -
C6N21_RS26410 5042235..5043359 + 1125 WP_072097015.1 DNA-binding protein -
C6N21_RS26415 5043356..5044096 + 741 WP_000788752.1 ATP-binding protein -
C6N21_RS26420 5044122..5044892 + 771 WP_000450862.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T97916 WP_001303876.1 NZ_CP027317:c5040084-5039797 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T97916 NZ_CP027317:c5040084-5039797 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT97916 WP_000536233.1 NZ_CP027317:c5040275-5040084 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT97916 NZ_CP027317:c5040275-5040084 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References