Detailed information of TA system TA097911

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 3438465..3439453
• Replicon: chromosome
• Accession: NZ_CP027317
• Organism: Escherichia coli strain 2015C-3107

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: C6N21_RS18145
• Protein ID: WP_014640052.1
• Coordinates: 3439067..3439453 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0A1AFM1
• Locus tag: C6N21_RS18140
• Protein ID: WP_000458583.1
• Coordinates: 3438465..3439037 (+)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6N21_RS18110	3433553..3434161	+	609	WP_000646078.1	transcriptional repressor LexA	-
C6N21_RS18115	3434234..3435559	+	1326	WP_001370252.1	MATE family efflux transporter DinF	-
C6N21_RS18120	3435675..3435884	+	210	WP_001030593.1	CsbD family protein	-
C6N21_RS18125	3435926..3436441	-	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
C6N21_RS18130	3436759..3437745	+	987	WP_000912572.1	DUF2713 domain-containing protein	-
C6N21_RS18135	3438108..3438230	+	123	WP_001300034.1	hypothetical protein	-
C6N21_RS18140	3438465..3439037	+	573	WP_000458583.1	SocA family protein	Antitoxin
C6N21_RS18145	3439067..3439453	+	387	WP_014640052.1	hypothetical protein	Toxin
C6N21_RS29630	3439493..3439666	+	174	WP_000390069.1	hypothetical protein	-
C6N21_RS18150	3439714..3439995	-	282	WP_001093921.1	pyocin activator PrtN family protein	-
C6N21_RS18155	3440032..3440604	-	573	WP_001061339.1	3'-5' exoribonuclease	-
C6N21_RS18160	3440604..3441338	-	735	WP_001094871.1	DUF551 domain-containing protein	-
C6N21_RS18165	3441341..3441532	-	192	WP_001014294.1	hypothetical protein	-
C6N21_RS18170	3441534..3442001	-	468	WP_000829413.1	hypothetical protein	-
C6N21_RS18175	3442148..3442621	-	474	WP_000145671.1	class I SAM-dependent methyltransferase	-
C6N21_RS18180	3442618..3442968	-	351	WP_001242740.1	hypothetical protein	-
C6N21_RS18185	3442959..3443294	-	336	WP_000543621.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7'	3433553..3495502	61949

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T97911 WP_014640052.1 NZ_CP027317:3439067-3439453 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T97911 NZ_CP027317:3439067-3439453 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGGGTCCCCCACGATCCGTCTTGCGTCTTGAATTCCGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21956.30 Da
• Isoelectric Point: 6.0283

>AT97911 WP_000458583.1 NZ_CP027317:3438465-3439037 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT97911 NZ_CP027317:3438465-3439037 [Escherichia coli]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGCATTGGTGACTACTGGTACAAC
TTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAGTT
GAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATTTGATCTCGCAAACATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Structures

Antitoxin

• AlphaFold DB: A0A0A1AFM1