Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2219475..2220273 | Replicon | chromosome |
| Accession | NZ_CP027317 | ||
| Organism | Escherichia coli strain 2015C-3107 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A3W5Y7S6 |
| Locus tag | C6N21_RS11815 | Protein ID | WP_000854916.1 |
| Coordinates | 2219896..2220273 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A3W5Y7S1 |
| Locus tag | C6N21_RS11810 | Protein ID | WP_024174207.1 |
| Coordinates | 2219475..2219849 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C6N21_RS11770 | 2215053..2215295 | - | 243 | WP_096855415.1 | transposase | - |
| C6N21_RS29310 | 2215537..2215806 | + | 270 | Protein_2184 | transposase | - |
| C6N21_RS29315 | 2215811..2216277 | - | 467 | Protein_2185 | transposase | - |
| C6N21_RS11780 | 2216315..2216668 | + | 354 | Protein_2186 | transposase | - |
| C6N21_RS11785 | 2216800..2217225 | + | 426 | WP_000422707.1 | IS66 family insertion sequence hypothetical protein | - |
| C6N21_RS11790 | 2217222..2217572 | + | 351 | WP_000624681.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| C6N21_RS11795 | 2217650..2218847 | - | 1198 | Protein_2189 | IS3 family transposase | - |
| C6N21_RS11800 | 2218888..2219022 | + | 135 | Protein_2190 | hypothetical protein | - |
| C6N21_RS11805 | 2219091..2219312 | + | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| C6N21_RS11810 | 2219475..2219849 | + | 375 | WP_024174207.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| C6N21_RS11815 | 2219896..2220273 | + | 378 | WP_000854916.1 | TA system toxin CbtA family protein | Toxin |
| C6N21_RS11820 | 2220270..2220758 | + | 489 | WP_000777666.1 | hypothetical protein | - |
| C6N21_RS11825 | 2220770..2220967 | + | 198 | WP_000839246.1 | DUF957 domain-containing protein | - |
| C6N21_RS29595 | 2221052..2221210 | + | 159 | WP_000014512.1 | hypothetical protein | - |
| C6N21_RS11830 | 2221228..2221386 | - | 159 | Protein_2197 | transposase domain-containing protein | - |
| C6N21_RS11835 | 2221412..2222624 | - | 1213 | Protein_2198 | IS3 family transposase | - |
| C6N21_RS11840 | 2222679..2224097 | - | 1419 | Protein_2199 | IS66 family transposase | - |
| C6N21_RS11845 | 2224117..2224464 | - | 348 | WP_000631725.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| C6N21_RS11850 | 2224461..2225135 | - | 675 | WP_001341423.1 | IS66 family insertion sequence hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2208315..2227426 | 19111 | |
| - | inside | IScluster/Tn | - | - | 2210783..2227426 | 16643 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14033.04 Da Isoelectric Point: 9.1378
>T97905 WP_000854916.1 NZ_CP027317:2219896-2220273 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIKAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITPGKHPEAKQ
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIKAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITPGKHPEAKQ
Download Length: 378 bp
>T97905 NZ_CP027317:2219896-2220273 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTA
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCCGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTA
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCCGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13789.59 Da Isoelectric Point: 6.7387
>AT97905 WP_024174207.1 NZ_CP027317:2219475-2219849 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLTIYPTPATATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLTIYPTPATATTS
Download Length: 375 bp
>AT97905 NZ_CP027317:2219475-2219849 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGACTATTTATCCGACACCGGCAACCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGACTATTTATCCGACACCGGCAACCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3W5Y7S6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3W5Y7S1 |