Detailed information of TA system TA097901

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1878673..1879510
• Replicon: chromosome
• Accession: NZ_CP027317
• Organism: Escherichia coli strain 2015C-3107

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A7U9LL67
• Locus tag: C6N21_RS10100
• Protein ID: WP_000854687.1
• Coordinates: 1879130..1879510 (+)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A7U9LJJ3
• Locus tag: C6N21_RS10095
• Protein ID: WP_001443392.1
• Coordinates: 1878673..1879041 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6N21_RS10060	1873779..1874162	+	384	Protein_1862	DUF932 domain-containing protein	-
C6N21_RS10065	1874672..1876450	+	1779	WP_001243192.1	reverse transcriptase/maturase family protein	-
C6N21_RS10070	1876569..1877009	+	441	Protein_1864	DUF932 domain-containing protein	-
C6N21_RS10075	1877009..1877254	+	246	WP_001164974.1	hypothetical protein	-
C6N21_RS10080	1877348..1877821	+	474	WP_000855068.1	antirestriction protein	-
C6N21_RS10085	1877837..1878313	+	477	WP_001186728.1	RadC family protein	-
C6N21_RS10090	1878376..1878597	+	222	WP_000692312.1	DUF987 domain-containing protein	-
C6N21_RS10095	1878673..1879041	+	369	WP_001443392.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
C6N21_RS10100	1879130..1879510	+	381	WP_000854687.1	TA system toxin CbtA family protein	Toxin
C6N21_RS10105	1879507..1879995	+	489	WP_001054228.1	hypothetical protein	-
C6N21_RS10110	1880015..1880212	+	198	WP_000772026.1	DUF957 domain-containing protein	-
C6N21_RS10115	1880297..1881142	+	846	WP_106875751.1	DUF4942 domain-containing protein	-
C6N21_RS10125	1881877..1884132	+	2256	WP_000491444.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 14199.13 Da
• Isoelectric Point: 6.8615

>T97901 WP_000854687.1 NZ_CP027317:1879130-1879510 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNNITLGRHPEEAKQ

Nucleotide

• Length: 381 bp

>T97901 NZ_CP027317:1879130-1879510 [Escherichia coli]
ATGAAAACATTACCCGACACTCACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCTCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATCCTCCGGGCCCGCAGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTAGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13781.54 Da
• Isoelectric Point: 6.2049

>AT97901 WP_001443392.1 NZ_CP027317:1878673-1879041 [Escherichia coli]
VSDTLHETNYPNDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLDDRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVALYAKGLTCDADTLGSCGYVYLAVYPTPDMKK

Nucleotide

• Length: 369 bp

>AT97901 NZ_CP027317:1878673-1879041 [Escherichia coli]
GTGTCAGACACACTCCATGAGACAAATTATCCCAACGACAATCACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGACGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGGCACTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGATATGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A7U9LL67

Antitoxin

• AlphaFold DB: A0A7U9LJJ3